Genetic findings of potential donor origin following hematopoietic cell transplantation: Recommendations on donor disclosure and genetic testing from the World Marrow Donor Association Guidelines

  

Authors:	Pryce, A.; Van Eerden, E.; Cody, M.; Oakes, J.; DeSalvo, A.; Bannon, S.; Burlton, C.; Pawson, R.; Fingrut, W.; Barriga, F.; Ward, J.; Ingram, C.; Walsh, M.; El-Ghariani, K.; Ocheni, S.; Machin, L.; Allan, D.; Mengling, T.; Anthias, C.
Title:	Genetic findings of potential donor origin following hematopoietic cell transplantation: Recommendations on donor disclosure and genetic testing from the World Marrow Donor Association
Abstract:	Following hematopoietic cell transplantation (HCT), recipients are subjected to extensive genetic testing to monitor the efficacy of the transplantation and identify relapsing malignant disease. This testing is increasingly including the use of large gene panels, which may lead to incidental identification of genetic and molecular information of potential donor origin. Deciphering whether variants are of donor origin, and if so, whether there are clinical implications for the donor can prove challenging. In response to queries from donor registries and transplant centers regarding best practices in managing donors when genetic mutations of potential donor origin are identified, the Medical Working Group of the World Marrow Donor Association established an expert group to review available evidence and develop a framework to aid decision making. These guidelines aim to provide recommendations on predonation consenting, postdonation testing of recipients, and informing and managing donors when findings of potential donor origin are identified in recipients post-transplantation. It is recognized that registries will have different access to resources and financing structures, and thus whenever possible, we have made suggestions on how recommendations can be adapted. © 2023 The American Society for Transplantation and Cellular Therapy
Keywords:	adult; bone marrow; practice guideline; hematopoietic stem cell transplantation; stem cell; donor; tissue donors; hematopoietic cell; interpersonal communication; genetic screening; therapy; genetic testing; ethics; cell transplantation; disclosure; transplant; humans; human; article; genetic findings; stem cell donor
Journal Title:	Transplantation and Cellular Therapy
Volume:	30
Issue:	2
ISSN:	2666-6375
Publisher:	Elsevier Inc.
Date Published:	2024-02-01
Start Page:	143
End Page:	154
Language:	English
DOI:	10.1016/j.jtct.2023.11.019
PUBMED:	38056629
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181244438&doi=10.1016%2fj.jtct.2023.11.019&partnerID=40&md5=e21b07baf64c90829d27d2df2d3f720e
Notes:	Article -- Source: Scopus

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