Clonal hematopoiesis and evolution to hematopoietic malignancies Journal Article


Authors: Bowman, R. L.; Busque, L.; Levine, R. L.
Article Title: Clonal hematopoiesis and evolution to hematopoietic malignancies
Abstract: Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood cells with one or more somatic mutations. Individuals with CH are at greater risk for hematological malignancies, cardiovascular disease, and increased mortality from non-hematological cancers. Understanding the causes of CH and how these mutant cells interact with cells of other tissues will provide critical insights into preleukemic development, stem cell biology, host-immune interactions, and cancer evolution. Here we discuss the clinical manifestations of CH, mechanisms contributing to its development, the role of CH in clonal evolution toward leukemia, and the contribution of CH to non-hematological disease states. Bowman et al. discuss the clinical manifestations of clonal hematopoiesis (CH), mechanisms contributing to its development, the role of CH in clonal evolution towards leukemia, and the contribution of CH to non-hematological disease states. © 2018 Elsevier Inc.
Keywords: gene mutation; janus kinase 2; review; nonhuman; dna methylation; hematologic malignancy; dna; epigenetics; cardiovascular disease; hematopoiesis; aging; flt3 ligand; malignant transformation; polycomb group protein; aplastic anemia; dna methyltransferase 3a; mosaicism; clonal evolution; human; priority journal; markov chain; hematopoietic system malignancy
Journal Title: Cell Stem Cell
Volume: 22
Issue: 2
ISSN: 1934-5909
Publisher: Cell Press  
Date Published: 2018-02-01
Start Page: 157
End Page: 170
Language: English
DOI: 10.1016/j.stem.2018.01.011
PROVIDER: scopus
PMCID: PMC5804896
PUBMED: 29395053
DOI/URL:
Notes: Review -- Export Date: 1 May 2018 -- Source: Scopus
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MSK Authors
  1. Ross Levine
    508 Levine
  2. Robert L Bowman
    22 Bowman