Urgent time to allogeneic hematopoietic cell transplantation: A national survey of transplant physicians and unrelated donor search coordinators facilitated by the Histocompatibility Advisory Group to the National Marrow Donor Program Journal Article

   

Authors:	Pidala, J.; Mupfudze, T. G.; Payton, T.; Barker, J.; Perales, M. A.; Shaw, B. E.; Fernandez-Vina, M.; Burns, L. J.; Dehn, J.
Article Title:	Urgent time to allogeneic hematopoietic cell transplantation: A national survey of transplant physicians and unrelated donor search coordinators facilitated by the Histocompatibility Advisory Group to the National Marrow Donor Program
Abstract:	To characterize donor search and selection practices, the National Marrow Donor Program (NMDP) Histocompatibility Advisory Group developed a survey of allogeneic hematopoietic cell transplant (HCT) physicians and search coordinators. The objectives were to describe search practices, understand practices surrounding urgent time to HCT, and characterize strategies used when identifying a matched unrelated donor is unlikely. Participants included US physician members of the American Society for Transplantation and Cellular Therapy and donor search coordinators within the NMDP network. The web-based survey was conducted from February to May 2018. Three hundred seventeen of 858 physicians (37%) and 225 of 327 coordinators (69%) responded, of which 263 and 194, respectively, were eligible and included in the analysis. Most centers, 142 (95%), were represented; 108 (72%) had at least 1 physician and 128 (85%) had at least 1 coordinator respondent. Most (68% physicians, 61% coordinators) indicated donor selection decisions were made by individual physicians. Urgent time to HCT was most commonly (90% and 87% of physicians and coordinators, respectively) defined as HO' within 4 to 6 weeks of search initiation. Higher HO' urgency was associated with a higher disease risk index. For urgent cases with low probability of an 8/8 matched unrelated donor , 75% and 80% of physicians and coordinators endorsed a short (1 to 2 weeks) unrelated donor search before proceeding to an alternative donor source. NMDP-provided solutions to expedite donor identification were strongly endorsed. This survey clarified current donor selection practices in the United States and defined urgent time to HO'. These data provide insight to NMDP on potential solutions to support the path to transplant, such as highlighting futile searches and providing alternative donor options at the time of search initiation. (C) 2019 Published by Elsevier Inc. on behalf of the American Society for Transplantation and Cellular Therapy
Keywords:	donor selection; transplant; allogeneic hematopoietic cell transplantation; national marrow donor program; allogeneic donors; urgent time to
Journal Title:	Biology of Blood and Marrow Transplantation
Volume:	25
Issue:	12
ISSN:	1083-8791
Publisher:	Elsevier Inc.
Date Published:	2019-12-01
Start Page:	2501
End Page:	2506
Language:	English
ACCESSION:	WOS:000505855900024
DOI:	10.1016/j.bbmt.2019.08.002
PROVIDER:	wos
PUBMED:	31419569
PMCID:	PMC7307219
Notes:	Article -- Source: Wos

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