Unrelated donor hematopoietic cell transplantation Book Section

  


Authors: Petersdorf, E. W.; Hsu, K.
Editors: Hoffman, R.; Benz, E. J. Jr; Silberstein, L. E.; Heslop, H. E.; Weitz, J. I.; Salama, M. E.; Abutalib, S. A.
Article/Chapter Title: Unrelated donor hematopoietic cell transplantation
Abstract: The outcomes of unrelated donor hematopoietic cell transplantation (HCT) have greatly improved as a result of a better understanding of the diversity of human leukocyte antigen (HLA) and killer-cell immunoglobulin-like receptors (KIR) genes. The HLA and KIR genetic systems regulate the transplantation barrier. Clinical outcomes after unrelated donor transplantation can be achieved with donor matching for the highly polymorphic HLA loci and through consideration of donor KIR genes. When HLA disparity cannot be avoided, judicious selection of a donor with the fewest HLA mismatches and avoidance of certain loci may provide patients with the opportunity for life-saving transplantation. Disease stage remains a strong predictor of overall transplant outcome, and expediency in the timing of transplantation for patients with high-risk diseases is paramount. New research avenues include the identification of major histocompatibility complex (MHC) and KIR genetic variation that may contribute to risks of GVHD and relapse. This chapter chronicles the role of HLA and KIR genes in unrelated donor HCT. © 2023 by Elsevier Inc. All rights reserved.
Keywords: natural killer cell; major histocompatibility complex; donor selection; hla; hematopoietic cell transplantation; unrelated donor; transplant outcome; killer immunoglobulin receptor
Book Title: Hematology: Basic Principles and Practice. 8th ed
ISBN: 978-032373388-5
Publisher: Elsevier Inc.  
Publication Place: Philadelphia, PA
Date Published: 2023-01-01
Start Page: 1703
End Page: 1712
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000581070&doi=10.1016%2fB978-0-323-73388-5.00106-1&partnerID=40&md5=565ce97b6a86a661a43baedbd9595dc7
Notes: Book chapter: 106 -- Source: Scopus