Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H(+)-adenosine triphosphatase Journal Article

  

Authors:	Kane, P. M.; Yamashiro, C. T.; Wolczyk, D. F.; Neff, N.; Goebl, M.; Stevens, T. H.
Article Title:	Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H(+)-adenosine triphosphatase
Abstract:	The TFP1 gene of the yeast Saccharomyces cerevisiae encodes two proteins: the 69-kilodalton (kD) catalytic subunit of the vacuolar proton-translocating adenosine triphosphatase (H+-ATPase) and a 50-kD protein. The 69-kD subunit is encoded by the 5′ and 3′ thirds of the TFP1 coding region, whereas the 50-kD protein is encoded by the central third. Evidence is presented that both the 69-kD and 50-kD proteins are obtained from a single translation product that is cleaved to release the 50-kD protein and spliced to form the 69-kD subunit.
Keywords:	animal; gene; protein; protein processing, post-translational; saccharomyces cerevisiae; rna, messenger; adenosine triphosphatase; rabbits; genes, fungal; vacuoles; priority journal; article; proton-translocating atpases; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; translation, genetic; saccaromyces
Journal Title:	Science
Volume:	250
Issue:	4981
ISSN:	0036-8075
Publisher:	American Association for the Advancement of Science
Date Published:	1990-11-02
Start Page:	651
End Page:	657
Language:	English
DOI:	10.1126/science.2146742
PUBMED:	2146742
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025226104&doi=10.1126%2fscience.2146742&partnerID=40&md5=d22dca87253a9bde59c008e65d15eb2a
Notes:	Article -- Export Date: 27 January 2020 -- Source: Scopus

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