Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes Journal Article

  

Authors:	Furneaux, H. F.; Reich, L.; Posner, J. B.
Article Title:	Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes
Abstract:	We measured the activity of 2 highly specific autoantibodies (anti-Yo associated with paraneoplastic cerebellar degeneration and anti-Hu associated with paraneoplastic sensory neuronopathy-encephalomyelitis) in simultaneously procured samples of serum and CSF of 18 patients. We also measured the effect of plasma exchange on autoantibody activity in serum and CSF of 6 patients. In 11 patients with paraneoplastic cerebellar degeneration, the CSF/serum ratio of anti-Yo antibody varied between 0.74 and 63, with 8 of 11 patients having ratios substantially greater than 1. In 7 patients with paraneoplastic sensory neuronopathy-encephalomyelitis, the CSF/serum ratio of anti-Hu antibody varied from 0.6 to 44, with 6 of 7 patients having ratios greater than 1. Plasmapheresis reduced the level of the autoantibody in serum without affecting that in the CSF in 5 of 6 patients. These data indicate that autoantibodies in paraneoplastic syndromes are produced in the CNS. This is consistent with the hypothesis of autoimmunity as the pathogenic mechanism. Plasmapheresis failed to effectively remove the antibody from the CNS. © 1990 American Academy of Neurology.
Keywords:	adult; clinical article; aged; aged, 80 and over; child, preschool; human cell; sensory neuropathy; plasmapheresis; central nervous system; immunoglobulin g; cerebrospinal fluid; autoantibody; paraneoplastic syndrome; autoantibodies; middle age; paraneoplastic syndromes; cerebellum degeneration; human; male; female; priority journal; article; support, u.s. gov't, p.h.s.
Journal Title:	Neurology
Volume:	40
Issue:	7
ISSN:	0028-3878
Publisher:	Lippincott Williams & Wilkins
Date Published:	1990-07-01
Start Page:	1085
End Page:	1091
Language:	English
PUBMED:	2356009
PROVIDER:	scopus
DOI:	10.1212/wnl.40.7.1085
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025321035&partnerID=40&md5=26335a14dde19299babfbc8cb4eb7a32
Notes:	Article -- Export Date: 27 January 2020 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/159572