Hematologic effects of interleukin-1β, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor in tumor-bearing mice treated with fluorouracil Journal Article


Authors: Moore, M. A. S.; Stolfi, R. L.; Martin, D. S.
Article Title: Hematologic effects of interleukin-1β, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor in tumor-bearing mice treated with fluorouracil
Abstract: Myelosuppression following intensive chemotherapy in cancer patients is associated with increased morbidity and mortality. Hematopoietic growth factors such as granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), alone or in combination with interleukin-1 (IL-1), have been shown to counteract myelosuppression resulting from some, but not all, chemotherapeutic regimens. In an attempt to apply these findings to intensive therapy with proliferation-dependent chemotherapeutic drugs such as fluorouracil (5-FU), we investigated combination biochemotherapy in a murine model. Female CD8F1 [(BALB/c × DBA/8)F1] mice bearing first-passage transplants of spontaneous CD8F1 breast tumors were treated intraperitoneally once a week for 3 successive weeks with a course of 5-FU alone or with a course of 5-FU in combination with recombinant human interleukin-1β (rHuIL-1β) alone or in combination with CSFs. rHuIL-1β alone or in combination with rHuG-CSF or recombinant murine GM-CSF significantly improved tumor growth inhibition (60% vs. 90%) and survival (20% vs. 90%-100%), increased the maximally tolerated dose of 5-FU, accelerated recovery of neutrophil counts in peripheral blood, and reduced duration of significant neutropenia and loss of body weight (29% vs. 10% loss). Clinical trials of IL-1 have been initiated in patients with advanced cancer receiving multiple courses of high-dose 5-FU. [J Natl Cancer inst 82:1031-1037, 1990] © 1990 Oxford University Press.
Keywords: cancer chemotherapy; fluorouracil; nonhuman; mouse; animal; mice; breast cancer; bone marrow; bone marrow suppression; granulocyte macrophage colony stimulating factor; interleukin 1beta; animal experiment; mice, inbred balb c; recombinant proteins; neoplasms, experimental; leukocyte count; granulocyte colony stimulating factor; granulocyte colony-stimulating factor; colony-stimulating factors; interleukin-1; growth substances; granulocyte-macrophage colony-stimulating factor; intraperitoneal drug administration; mice, inbred dba; female; priority journal; article
Journal Title: JNCI: Journal of the National Cancer Institute
Volume: 82
Issue: 12
ISSN: 0027-8874
Publisher: Oxford University Press  
Date Published: 1990-06-20
Start Page: 1031
End Page: 1037
Language: English
DOI: 10.1093/jnci/82.12.1031
PUBMED: 1693405
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 27 January 2020 -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Malcolm A S Moore
    549 Moore