| Abstract: |
In a cytogenetic analysis of 9 gastric and lower esophageal adenocarcinomas, we detected nonrandom rearrangements involving the region llpl3–15 in 8, thus identifying for the first time a specific chromosomal lesion in these tumors. In addition, rearrangements involving 3p21, translocations among the D group chromosomes, and i(5p) were each observed in more than half of the cases. The overall pattern of aberrations encountered in adenocarcinomas of gastric and lower esophageal origin was similar, suggesting that the tumors arising at these anatomical sites are biologically related. We also encountered cytogenetic evidence for gene amplification in the form of homogeneously staining regions and double-minute chromosomes in primary as well as metastatic lesions, which is consistent with amplification of a number of cellular oncogenes in these tumors detected by others and us at the molecular level. These cytogenetic findings are discussed in relation to nonrandom chromosome abnormalities and gene amplification reported in other types of adenocarcinoma. © 1990, American Association for Cancer Research. All rights reserved. |
| Keywords: |
clinical article; human cell; adenocarcinoma; cytology; histology; gene rearrangement; stomach cancer; chromosome rearrangement; karyotyping; stomach neoplasms; chromosomes, human, pair 11; esophagus carcinoma; esophageal neoplasms; chromosome mapping; chromosome banding pattern; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; translocation (genetics)
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