Cytogenetics of gastric and esophageal adenocarcinomas: 3q deletion as a possible primary chromosomal change Journal Article
| Authors: | Rao, P. H.; Mathew, S.; Kelsen, D. P.; Chaganti, R. S. K. |
| Article Title: | Cytogenetics of gastric and esophageal adenocarcinomas: 3q deletion as a possible primary chromosomal change |
| Abstract: | We report clonal chromosome abnormalities in short term cultures of seven gastric or esophageal adenocarcinomas and two squamous carcinomas of the esophagus and EG junction. The most consistent aberration encountered was a del(3)(q13.2q23) seen in six of nine tumors. This finding, together with a survey of published cytogenetic literature, suggested that del(3q) is the most common cytogenetic abnormality, and hence possibly of primary significance, in these tumors. In addition to del(3q), rearrangements affecting 1p13 (two cases), 6q15-q23 (two cases), 7p22 (two cases), 7q22 (two cases), and 11p11.2-p14 (three cases) were seen. Cytogenetic evidence for gene amplification in the form of homogeneously staining region (hsr) was seen at 9q13 in two cases. © 1995. |
| Keywords: | adult; human tissue; aged; aged, 80 and over; human cell; adenocarcinoma; gene amplification; cytogenetics; chromosome aberration; chromosome rearrangement; chromosome deletion; stomach adenocarcinoma; chromosome analysis; karyotyping; stomach neoplasms; esophagus carcinoma; esophageal neoplasms; chromosome 3q; middle age; chromosome 9q; human; male; female; priority journal; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Cancer Genetics and Cytogenetics |
| Volume: | 81 |
| Issue: | 2 |
| ISSN: | 0165-4608 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1995-06-01 |
| Start Page: | 139 |
| End Page: | 143 |
| Language: | English |
| DOI: | 10.1016/0165-4608(94)00113-p |
| PUBMED: | 7621410 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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