Malignant tumors of major salivary gland origin: A matched-pair analysis of the role of combined surgery and postoperative radiotherapy Journal Article
| Authors: | Armstrong, J. G.; Harrison, L. B.; Spiro, R. H.; Fass, D. E.; Strong, E. W.; Fuks, Z. Y. |
| Article Title: | Malignant tumors of major salivary gland origin: A matched-pair analysis of the role of combined surgery and postoperative radiotherapy |
| Abstract: | Between 1966 and 1982, 46 patients with previously untreated malignant tumors of major salivary gland origin received combined surgery and postoperative radiotherapy. They were compared with 46 patients treated with surgery only between 1939 and 1965, who were matched according to prognostic criteria. Radiation doses ranged from 4000 to 7740 cGy (median, 5664 cGy). The 5-year determinate survival rates for patients given combined therapy with stage I and II disease vs patients given surgery only was 81.9% vs 95.8%, while for stages III and IV it was 51.2% vs 9.5%, respectively. Local control for stage III and IV disease in patients given combined therapy vs patients given surgery only at 5 years was 51.3% vs 16.8%. For patients with nodal metastases, 5-year determinate survival for the combined-therapy group vs the surgery-only group was 48.9% vs 18.7%, and the corresponding local-regional control was 69.1% vs 40.2%. The results of this analysis suggest that postoperative radiotherapy significantly improves outcome for patients with stage III and IV disease and for patients with lymph node metastases. (Arch Otolaryngol Head Neck Surg. 1990;116:290-293). © 1990, American Medical Association. All rights reserved. |
| Keywords: | adult; aged; survival rate; neck dissection; cancer radiotherapy; comparative study; postoperative care; combined modality therapy; cancer staging; methodology; follow-up studies; classification; radiotherapy dosage; time factors; salivary gland neoplasms; salivary gland cancer; middle age; neck metastasis; parotid gland cancer; submandibular gland; human; male; female; priority journal; article |
| Journal Title: | Archives of Otolaryngology - Head & Neck Surgery |
| Volume: | 116 |
| Issue: | 3 |
| ISSN: | 0886-4470 |
| Publisher: | American Medical Association |
| Date Published: | 1990-03-01 |
| Start Page: | 290 |
| End Page: | 293 |
| Language: | English |
| DOI: | 10.1001/archotol.1990.01870030054008 |
| PUBMED: | 2306346 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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