Squamous cancer of the anus Journal Article

  


Authors: Quan, S. H. Q.; Miller, E. J.
Article Title: Squamous cancer of the anus
Abstract: A series of 42 patients treated for epidermoid cancer of the anal canal, between 1977 and 1985, is presented. Patients with carcinoma of the anal margin were not included. The dentate line is the anatomic landmark to distinguish between the two. For more than 10 years, a combined therapy of preoperative chemotherapy and radiotherapy prior the consideration of surgery has been used at Memorial Hospital. On day one an intravenous bolus of Mitomycin C (15 mg/m2) was given and a 5 day continuous infusion of 5 Fluoro-uracil (750 mg/m2/day) started. External beam irradiation (3000 cGy) was performed from day 7 to day 28, 5 times a week using 200cGy per treatment. Surgical evaluation took place 6 to 8 weeks later, even if the tumour had totally disappeared. Twenty-three patients (55 %) had a wide full thickness local excision of the tumour site. A subsequent abdominoperineal resection had to be performed because positive margins were found in 2 patients and for locally recurrent disease in 3 patients. Abdominoperineal resection was performed as the initial operation in 18 patients (43 %). The last patient underwent exploratory laparotomy with the findings of bilobar hepatic metastases. The overall 5 year survival rate was 82 %, and anal continence was maintained in 43 % of the patients. These results are discussed and compared to historical series at Memorial Hospital.
Journal Title: Lyon Chirurgical
Volume: 87
Issue: 1
ISSN: 0024-7782
Publisher: Lyon Chirurgical  
Date Published: 1991-01-01
Start Page: 53
End Page: 56
Language: French
ACCESSION: WOS:A1991FC44800016
PROVIDER: wos
Notes: Article; Proceedings Paper -- INTERNATIONAL SYMP ON RADIO-SURGICAL TREATMENT OF RECTAL AND ANAL TUMOURS -- JUN 01, 1990 -- LYON, FRANCE -- Source: Wos