The influence of extensive bone erosion on local control in non-orbital rhabdomyosarcoma of the head and neck Conference Paper
| Authors: | Mandell, L. R.; Massey, V.; Ghavimi, F. |
| Title: | The influence of extensive bone erosion on local control in non-orbital rhabdomyosarcoma of the head and neck |
| Conference Title: | 30th Annual Meeting of the American Society for Therapeutic Radiology and Oncology |
| Abstract: | To investigate a recent report suggesting extensive bone erosion (EBE) as an important prognostic factor in head and neck rhabdomyosarcoma, a retrospective review was performed of 32 patients with gross residual and/or metastatic non-orbital head and neck rhabdomyosarcoma treated between the years 1971-1987. Treatment consisted of surgery, radiation therapy (median primary dose, 5000 cGy) and combination chemotherapy according to the Memorial Sloan-Kettering Cancer Center (MSKCC) T2 and T6 protocols. The MSKCC staging system was used: Stage II, 23 patients; Stage III, 6 patients; and Stage IV, 3 patients. With a median follow-up of 48 months range 17 months to 13 years), the overall survival and local control rates were 72% ( 23 32) and 75% ( 24 32), respectively. Local control was achieved in 11 11 patients without extensive bone erosion (Stages II, 9 9; III, 1 1; IV, 1 1)as compared to 13 21 patients (Stages II, 10 14; III, 2 5; IV, 1 2) with extensive bone erosion (p = 0.02). Our data appear to support the recently reported finding that extensive bone erosion is an important predictor of local failure. © 1989. |
| Keywords: | adolescent; adult; cancer chemotherapy; child; clinical article; child, preschool; cancer surgery; retrospective studies; doxorubicin; combined modality therapy; cancer staging; cyclophosphamide; vincristine; histology; infant; head and neck cancer; head and neck neoplasms; dactinomycin; bone and bones; rhabdomyosarcoma; orbital neoplasms; intravenous drug administration; megavoltage radiotherapy; bone erosion; prognosis; human; male; female; priority journal; extensive bone erosion; non-orbital head and neck rhabdomyosarcoma |
| Journal Title | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 17 |
| Issue: | 3 |
| Conference Dates: | 1988 Oct 9-14 |
| Conference Location: | New Orleans, LA |
| ISBN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1989-09-01 |
| Start Page: | 649 |
| End Page: | 653 |
| Language: | English |
| DOI: | 10.1016/0360-3016(89)90118-1 |
| PUBMED: | 2777653 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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