The spliceosome as an indicted conspirator in myeloid malignancies Journal Article

   


Authors: Abdel-Wahab, O.; Levine, R.
Article Title: The spliceosome as an indicted conspirator in myeloid malignancies
Abstract: Reports of whole-exome sequencing in myelodysplastic syndrome (MDS) patients by Yoshida et al. and Papaemmanuil et al. suggest spliceosome mutations have clinical relevance. Identifying the impact of these mutations on MDS pathogenesis holds promise for therapeutic modulation of mRNA splicing. © 2011 Elsevier Inc.
Keywords: cancer survival; gene mutation; somatic mutation; frameshift mutation; missense mutation; pathogenesis; nonhuman; gene expression; genetic transcription; carcinogenesis; hematologic malignancy; myelodysplastic syndrome; messenger rna; short survey; hematopoiesis; hematopoietic stem cell; spliceosome; point mutation; nonsense mutation; rna splicing; polycomb group protein; open reading frame; ribonucleoprotein; serine arginine rich protein
Journal Title: Cancer Cell
Volume: 20
Issue: 4
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2011-10-18
Start Page: 420
End Page: 422
Language: English
DOI: 10.1016/j.ccr.2011.10.004
PROVIDER: scopus
PMCID: PMC3218079
PUBMED: 22014568
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-80054747873&partnerID=40&md5=87f43f86dc886d7618c52cf4e4419e2b
Notes: --- - "Export Date: 9 December 2011" - "CODEN: CCAEC" - "Source: Scopus"
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MSK Authors
  1. Ross Levine
    775 Levine
  2. Omar Ibrahim Abdel-Wahab
    573 Abdel-Wahab
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