It dices, it splices! Journal Article
| Author: | Klimek, V. M. |
| Article Title: | It dices, it splices! |
| Abstract: | A novel class of molecular lesions that affect components of the splicing machinery is the focus of the work by Malcovati et al. in this issue of Blood.1 Their data confirm the strong correlation between splicing factor SF3B1 mutations and the presence of ringed sideroblasts in patients with myelodysplastic syndromes (MDS). In addition, they show an improved survival for patients with SF3B1 mutations independent of the International Prognostic Scoring System (IPSS). |
| Keywords: | survival; cancer survival; unclassified drug; gene mutation; overall survival; mutation; note; disease free survival; phenotype; gene frequency; transcription factor; heterozygote; wild type; myelodysplastic syndrome; thrombosis; acute myeloblastic leukemia; alternative rna splicing; thrombocyte count; phosphoproteins; world health organization; leukocyte count; catalysis; spliceosome; point mutation; small nuclear ribonucleoprotein; rna splicing; myelodysplastic syndromes; rna sequence; ribonucleoprotein, u2 small nuclear; splicing factor sf3b1; exome; sideroblastic anemia; myelodysplastic-myeloproliferative diseases |
| Journal Title: | Blood |
| Volume: | 118 |
| Issue: | 24 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2011-12-02 |
| Start Page: | 6237 |
| End Page: | 6238 |
| Language: | English |
| DOI: | 10.1182/blood-2011-10-386540 |
| PROVIDER: | scopus |
| PUBMED: | 22161850 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 January 2012" - "CODEN: BLOOA" - "Source: Scopus" |
