Role of the commensal microbiota in normal and pathogenic host immune responses Journal Article


Authors: Littman, D. R.; Pamer, E. G.
Article Title: Role of the commensal microbiota in normal and pathogenic host immune responses
Abstract: The commensal microbiota that inhabit different parts of the gastrointestinal (GI) tract have been shaped by coevolution with the host species. The symbiotic relationship of the hundreds of microbial species with the host requires a tuned response that prevents host damage, e.g., inflammation, while tolerating the presence of the potentially beneficial microbes. Recent studies have begun to shed light on immunological processes that participate in maintenance of homeostasis with the microbiota and on how disturbance of host immunity or the microbial ecosystem can result in disease-provoking dysbiosis. Our growing appreciation of this delicate host-microbe relationship promises to influence our understanding of inflammatory diseases and infection by microbial pathogens and to provide new therapeutic opportunities. © 2011 Elsevier Inc.
Keywords: review; nonhuman; animals; infection; models, biological; inflammation; immunological tolerance; immune response; gastrointestinal tract; homeostasis; host pathogen interaction; commensal; microflora; metagenome; symbiosis
Journal Title: Cell Host & Microbe
Volume: 10
Issue: 4
ISSN: 1931-3128
Publisher: Cell Press  
Date Published: 2011-10-20
Start Page: 311
End Page: 323
Language: English
DOI: 10.1016/j.chom.2011.10.004
PROVIDER: scopus
PMCID: PMC3202012
PUBMED: 22018232
DOI/URL:
Notes: --- - "Export Date: 9 December 2011" - "Source: Scopus"
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Eric Pamer
    283 Pamer