Noninvasive cell-tracking methods Journal Article
| Authors: | Kircher, M. F.; Gambhir, S. S.; Grimm, J. |
| Article Title: | Noninvasive cell-tracking methods |
| Abstract: | Cell-based therapies, such as adoptive immunotherapy and stem-cell therapy, have received considerable attention as novel therapeutics in oncological research and clinical practice. The development of effective therapeutic strategies using tumor-targeted cells requires the ability to determine in vivo the location, distribution, and long-term viability of the therapeutic cell populations as well as their biological fate with respect to cell activation and differentiation. In conjunction with various noninvasive imaging modalities, cell-labeling methods, such as exogenous labeling or transfection with a reporter gene, allow visualization of labeled cells in vivo in real time, as well as monitoring and quantifying cell accumulation and function. Such cell-tracking methods also have an important role in basic cancer research, where they serve to elucidate novel biological mechanisms. In this Review, we describe the basic principles of cell-tracking methods, explain various approaches to cell tracking, and highlight recent examples for the application of such methods in animals and humans. © 2011 Macmillan Publishers Limited. All rights reserved. |
| Journal Title: | Nature Reviews Clinical Oncology |
| Volume: | 8 |
| Issue: | 11 |
| ISSN: | 1759-4774 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2011-11-01 |
| Start Page: | 677 |
| End Page: | 688 |
| Language: | English |
| DOI: | 10.1038/nrclinonc.2011.141 |
| PROVIDER: | scopus |
| PUBMED: | 21946842 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "Source: Scopus" |
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