CD5 negative, cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) presenting as ruptured spleen Journal Article

  


Authors: Teruya-Feldstein, J.; Gopalan, A.; Moskowitz, C. H.
Article Title: CD5 negative, cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) presenting as ruptured spleen
Abstract: We present a case of diffuse large B-cell lymphoma CD5 negative, Cyclin D1 positive presenting as ruptured spleen in a 63-year-old man requiring emergent splenectomy. Tumor cells showed marked pleomorphism, anaplasia, and increased mitotic figures with positive Cyclin D1, BCL6, MUM1, P53, and a high MIB1 proliferative fraction. The patient received multiple therapies and ultimately died. This case raises the differential diagnoses of pleomorphic mantle cell lymphoma and other aggressive lymphomas with pleomorphic, anaplastic, and Reed-Sternberg-like cells. © 2009 Lippincott Williams & Wilkins, Inc.
Keywords: adult; cancer chemotherapy; human tissue; middle aged; prednisone; splenectomy; case report; doxorubicin; rituximab; positron emission tomography; antineoplastic agent; ki 67 antigen; carboplatin; bortezomib; computer assisted tomography; mantle cell lymphoma; multiple cycle treatment; diagnosis, differential; ubiquitin protein ligase; etoposide; antineoplastic combined chemotherapy protocols; differential diagnosis; cyclophosphamide; vincristine; protein p53; ifosfamide; b cell lymphoma; splenomegaly; tumor suppressor protein p53; large cell lymphoma; lymphoma, large b-cell, diffuse; cyclin d1; rupture, spontaneous; fatal outcome; cd5 antigen; ubiquitin-protein ligases; lymphadenopathy; anaplastic carcinoma; spleen rupture; splenic rupture; cd5 negative; cyclin d1-positive dlbcl; pleomorphic mantle cell lymphoma; mib1 protein, human; fatality; rupture; antigens, cd5
Journal Title: Applied Immunohistochemistry & Molecular Morphology
Volume: 17
Issue: 3
ISSN: 1541-2016
Publisher: Lippincott Williams & Wilkins  
Date Published: 2009-05-01
Start Page: 255
End Page: 258
Language: English
DOI: 10.1097/PAI.0b013e318182d2aa
PUBMED: 18838919
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-66549097996&partnerID=40&md5=0eaaf4f02853a743ecd0cd0b8af48e1a
Notes: --- - "Export Date: 30 November 2010" - "CODEN: AIMMF" - "Source: Scopus"
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MSK Authors
  1. Craig Moskowitz
    407 Moskowitz
  2. Julie T Feldstein
    297 Feldstein
  3. Anuradha Gopalan
    416 Gopalan
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