Cytology of extranodal Ki-1 anaplastic large cell lymphoma Journal Article
| Authors: | Zakowski, M. F.; Feiner, H.; Finfer, M.; Thomas, P.; Wollner, N.; Filippa, D. A. |
| Article Title: | Cytology of extranodal Ki-1 anaplastic large cell lymphoma |
| Abstract: | Ki-1-positive anaplastic large-cell lymphoma (ALCL) is an uncommon neoplasm which may present with extranodal as well as nodal disease. By definition, the tumor cells are immunoreactive for Ki-1 or Ber-H2 antigen (CD30). There have been few published cytologic descriptions of this lymphoma, or of its detection in extranodal sites. We describe the cytologic findings in five cases of extranodal Ki-1 lymphoma. Cytologic findings in all five cases were similar and consisted of a heterogeneous population of lymphocytes and bizarre, pleomorphic tumor cells. These cells were characterized by generous amounts of vacuolated, basophilic cytoplasm, eccentric, multilobulated nuclei with some showing 'wreath-like' configurations. Some nuclei contained huge nucleoli simulating Reed-Sternberg cells. All cases showed the characteristic surface membrane and cytoplasmic paranuclear dotlike staining for CD30. Our findings indicate that fine- needle aspiration and exfoliative cytology have a useful role in the diagnosis of Ki-1 ALCL in extranodal sites. Furthermore, effusions containing anaplastic cells suspicious for lymphoma, particularly in AIDS patients, should be immunostained with antibodies to CD30. |
| Keywords: | immunohistochemistry; adolescent; adult; human tissue; bone neoplasms; retrospective studies; ascites; lymph nodes; prospective studies; cytology; cell population; immunoreactivity; needle biopsy; urinary bladder; bone; large cell lymphoma; aspiration biopsy; frozen section; pericardium; pleura; anaplastic carcinoma; ascitic fluid; cytodiagnosis; cd30 antigen; reed sternberg cell; fine-needle aspiration; lymphoma, large-cell, ki-1; humans; human; priority journal; article; cd30, ber-h2; exfoliative cytology |
| Journal Title: | Diagnostic Cytopathology |
| Volume: | 14 |
| Issue: | 2 |
| ISSN: | 8755-1039 |
| Publisher: | Wiley Liss |
| Date Published: | 1996-03-01 |
| Start Page: | 155 |
| End Page: | 161 |
| Language: | English |
| DOI: | 10.1002/(sici)1097-0339(199603)14:2<155::aid-dc10>3.0.co;2-l |
| PUBMED: | 8964173 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work