Immunoengineering in glioblastoma imaging and therapy Journal Article


Authors: Zanganeh, S.; Georgala, P.; Corbo, C.; Arabi, L.; Ho, J. Q.; Javdani, N.; Sepand, M. R.; Cruickshank, K.; Campesato, L. F.; Weng, C. H.; Hemayat, S.; Andreou, C.; Alvim, R.; Hutter, G.; Rafat, M.; Mahmoudi, M.
Article Title: Immunoengineering in glioblastoma imaging and therapy
Abstract: Patients diagnosed with glioblastoma have poor prognosis. Conventional treatment strategies such as surgery, chemotherapy, and radiation therapy demonstrated limited clinical success and have considerable side effects on healthy tissues. A central challenge in treating brain tumors is the poor permeability of the blood–brain barrier (BBB) to therapeutics. Recently, various methods based on immunotherapy and nanotechnology have demonstrated potential in addressing these obstacles by enabling precise targeting of brain tumors to minimize adverse effects, while increasing targeted drug delivery across the BBB. In addition to treating the tumors, these approaches may be used in conjunction with imaging modalities, such as magnetic resonance imaging and positron emission tomography to enhance the prognosis procedures. This review aims to provide mechanistic understanding of immune system regulation in the central nervous system and the benefits of nanoparticles in the prognosis of brain tumors. This article is characterized under:. Diagnostic Tools ' in vivo Nanodiagnostics and Imaging. Nanotechnology Approaches to Biology ' Cells at the Nanoscale. Nanotechnology Approaches to Biology ' Nanoscale Systems in Biology. © 2019 Wiley Periodicals, Inc.
Keywords: review; doxorubicin; chemotherapy; neuroimaging; positron emission tomography; brain tumor; magnetic resonance imaging; cancer immunotherapy; patient monitoring; immunoregulation; immunotherapy; brain; radiation effects; tumors; glioblastoma; diagnosis; cancer stem cell; imaging; medical nanotechnology; nanomedicine; central nervous systems; radiosensitizing agent; quantum dot; drug delivery system; nanotechnology; photosensitizing agent; imaging techniques; nanopharmaceutics; targeted drug delivery; glioblastomas; imaging modality; dendrimer; cancer prognosis; gold nanoparticle; superparamagnetic iron oxide nanoparticle; human; priority journal; conventional treatments; immunoengineering; theranostic nanomedicine; nano-scale system; system regulation; carbon nanoparticle
Journal Title: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume: 11
Issue: 6
ISSN: 1939-5116
Publisher: Wiley Periodicals, Inc  
Date Published: 2019-11-01
Start Page: e1575
Language: English
DOI: 10.1002/wnan.1575
PUBMED: 31407522
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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