Breast cancer brain metastases: Achilles’ heel in breast cancer patients’ care Journal Article
| Authors: | Ferraro, E.; Seidman, A. D. |
| Editors: | Al Jarroudi, O.; El Bairi, K.; Curigliano, G. |
| Article Title: | Breast cancer brain metastases: Achilles’ heel in breast cancer patients’ care |
| Abstract: | Brain metastases (BM) significantly affect the prognosis as well as the quality of life of breast cancer (BC) patients. Although advancements in neurosurgical and radiotherapy techniques improve local control and symptom management, BM remains associated with a poor prognosis. In addition, the efficacy of currently approved systemic therapies in central nervous system (CNS) compartment is still limited, especially after progression on local therapy. The blood-brain barrier (BBB) has been recognized as a mechanism of primary resistance to many chemotherapeutic agents and targeted therapies due to low drug penetration. Other mechanisms of primary and secondary resistance are still unclear and may vary across the BC subtypes. New small molecules have demonstrated efficacy in BM, in particular for the HER2-positive subtype, with a benefit in survival. A new era has begun in the field of BM, and many trials specifically designed for this population are currently ongoing. The BC research community needs to address this call with the final aim of improving the efficacy of systemic therapy in CNS compartment and ultimately preventing the occurrence of BM. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023. |
| Keywords: | cancer survival; fluorouracil; capecitabine; paclitaxel; brain tumor; brain neoplasms; cancer incidence; progression free survival; quality of life; breast cancer; cyclophosphamide; breast neoplasms; patient care; breast tumor; brain metastasis; epirubicin; craniotomy; trastuzumab; lapatinib; neratinib; triple negative breast cancer; central nervous system metastases; her2-positive breast cancer; humans; human; female; abemaciclib; vinorelbine tartrate; tucatinib; sacituzumab |
| Journal Title: | Cancer Treatment and Research |
| Volume: | 188 |
| ISSN: | 0927-3042 |
| Publisher: | Springer |
| Date Published: | 2023-01-01 |
| Start Page: | 283 |
| End Page: | 302 |
| Language: | English |
| DOI: | 10.1007/978-3-031-33602-7_11 |
| PROVIDER: | scopus |
| PUBMED: | 38175350 |
| DOI/URL: | |
| Notes: | This book chapter is part of the book Cancer Treatment and Research: Innovative Concepts (978-3-031-33601-0) -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work