New frontiers in translational research in neuro-oncology and the blood-brain barrier: Report of the Tenth Annual Blood-brain Barrier Disruption Consortium Meeting Journal Article
| Authors: | Doolittle, N. D.; Abrey, L. E.; Bleyer, W. A.; Brem, S.; Davis, T. P.; Dore-Duffy, P.; Drewes, L. R.; Hall, W. A.; Hoffman, J. M.; Korfel, A.; Martuza, R.; Muldoon, L. L.; Peereboom, D.; Peterson, D. R.; Rabkin, S. D.; Smith, Q.; Stevens, G. H. J.; Neuwelt, E. A. |
| Article Title: | New frontiers in translational research in neuro-oncology and the blood-brain barrier: Report of the Tenth Annual Blood-brain Barrier Disruption Consortium Meeting |
| Abstract: | The blood-brain barrier (BBB) presents a major obstacle to the treatment of malignant brain tumors and other central nervous system (CNS) diseases. For this reason, a meeting partially funded by an NIH R13 grant was convened to discuss recent advances and future directions in translational research in neuro-oncology and the BBB. Cell biology and transport across the BBB, delivery of agents to the CNS, neuroimaging, angiogenesis, immunotherapy, and gene therapy, as well as glioma, primary CNS lymphoma, and metastases to the CNS were discussed. Transport across the BBB relates to the neurovascular unit, which consists not only of endothelial cells but also of pericyte, glia, and neuronal elements. |
| Keywords: | unclassified drug; human cell; thalidomide; angiogenesis inhibitor; erlotinib; antineoplastic agents; conference paper; combined modality therapy; gadolinium; methotrexate; temozolomide; brain tumor; glioma; brain neoplasms; magnetic resonance imaging; cytology; carboplatin; etoposide; diagnostic imaging; angiogenesis; drug delivery systems; endothelium cell; immunotherapy; cancer vaccine; medical research; blood brain barrier; blood-brain barrier; brain metastasis; gene therapy; organization; medical oncology; antioxidant; navelbine; cell transport; cadherin; nerve cell; biological transport; methionine; glutathione; ultrasmall superparamagnetic iron oxide; neurology; glia; central nervous system disease; brain lymphoma; pericyte; thiol derivative; oncological parameters; acetylcysteine; 1 (2 chloroethyl) 3 (2,6 dioxo 3 piperidyl) 1 nitrosourea; exherin; sodium thiosulfate; drug implants |
| Journal Title: | Clinical Cancer Research |
| Volume: | 11 |
| Issue: | 2 I |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2005-01-15 |
| Start Page: | 421 |
| End Page: | 428 |
| Language: | English |
| PUBMED: | 15701824 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 25" - "Export Date: 24 October 2012" - "CODEN: CCREF" - "Source: Scopus" |
