Salvage surgery for recurrent larynx cancer Journal Article
| Authors: | Mimica, X.; Hanson, M.; Patel, S. G.; McGill, M.; McBride, S.; Lee, N.; Dunn, L. A.; Cracchiolo, J. R.; Shah, J. P.; Wong, R. J.; Ganly, I.; Cohen, M. A. |
| Article Title: | Salvage surgery for recurrent larynx cancer |
| Abstract: | Background: Despite advances in treatment, the recurrence rates for laryngeal cancer range from 16% to 40%. Methods: Patients with recurrent laryngeal cancer treated at Memorial Sloan Kettering (MSK) from 1999 to 2016 were reviewed. Survival outcomes were analyzed. Results: Of 241 patients, 88% were male; the median age was 67 years; 71% had primary glottic tumors. At initial treatment, 72% of patients were seen with early stage disease; primary treatment was radiation (68%), chemoradiation (29%), and surgery (3%). The most common salvage surgery was total laryngectomy (74%). Forty-seven percentage were upstaged at salvage surgery. The 2- and 5-year disease-specific survival (DSS) was 74% and 57%, respectively. Patients with cT4 disease treated with nonsurgical primary management had a 0% 5-year DSS. Independent predictors of DSS were tumor location, perineural invasion, margin, and stage. Conclusions: Salvage surgery results in acceptable oncologic outcomes. Stage, disease site, perineural invasion, and margins are associated with inferior DSS. © 2019 Wiley Periodicals, Inc. |
| Keywords: | adult; cancer survival; clinical article; human tissue; aged; cancer surgery; primary tumor; treatment failure; overall survival; histopathology; cancer recurrence; laryngectomy; salvage therapy; cisplatin; cancer radiotherapy; cancer staging; antineoplastic agent; tumor localization; medical record review; retrospective study; endoscopic surgery; recurrent disease; larynx cancer; disease specific survival; perineural invasion; chemoradiotherapy; larynx surgery; surgical margin; cancer prognosis; head and neck neoplasm; prognosis; human; male; female; priority journal; article; larynx squamous cell carcinoma; salvage laryngectomy; distant recurrence free survival |
| Journal Title: | Head & Neck |
| Volume: | 41 |
| Issue: | 11 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2019-11-01 |
| Start Page: | 3906 |
| End Page: | 3915 |
| Language: | English |
| DOI: | 10.1002/hed.25925 |
| PUBMED: | 31433540 |
| PROVIDER: | scopus |
| PMCID: | PMC7485603 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2019 -- Source: Scopus |
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