Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study Journal Article
| Authors: | Maghami, E. G.; Talbot, S. G.; Patel, S. G.; Singh, B.; Polluri, A.; Bridger, P. G.; Cantu, G.; Cheesman, A. D.; De Sa, G.; Donald, P.; Dos Santos, L. R. M.; Fliss, D.; Gullane, P.; Janecka, I.; Kamata, S. E.; Kowalski, L. P.; Kraus, D. H.; Levine, P. A.; Pradhan, S.; Schramm, V.; Snyderman, C.; Wei, W. I.; Shah, J. P. |
| Article Title: | Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study |
| Abstract: | Background. This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC). Methods. One hundred twenty patients who underwent CFS for NMSC were identified from 17 participating institutions. Patient, tumor, and treatment information was analyzed for prognostic impact on survival. Results. Surgical margins were negative in 74%, close in 3%, and involved in 23% of patients. Complications occurred in 35% of patients, half of which were local wound problems. Operative mortality was 4%. Median follow-up interval after CFS was 27 months. The 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were 64%, 75%, and 60%, respectively. Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS. Conclusion. CFS is an effective treatment for patients with NMSC invading the skull base. Histology, extent of disease, and resection margins are the most significant predictors of outcome. © 2007 Wiley Periodicals, Inc. |
| Keywords: | adolescent; adult; cancer survival; child; controlled study; treatment outcome; aged; aged, 80 and over; child, preschool; disease-free survival; middle aged; major clinical study; review; cancer recurrence; squamous cell carcinoma; carcinoma, squamous cell; surgical flaps; advanced cancer; disease free survival; chemotherapy, adjuvant; radiotherapy, adjuvant; follow up; brain neoplasms; follow-up studies; basal cell carcinoma; skin neoplasms; skin cancer; cancer mortality; postoperative complication; postoperative complications; cancer invasion; neoplasm invasiveness; carcinoma, basal cell; head and neck; craniofacial surgery; skull neoplasms; international cooperation; surgical wound; international collaboration; skull base neoplasm; skull base/craniofacial surgery |
| Journal Title: | Head & Neck |
| Volume: | 29 |
| Issue: | 12 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2007-12-01 |
| Start Page: | 1136 |
| End Page: | 1143 |
| Language: | English |
| DOI: | 10.1002/hed.20656 |
| PUBMED: | 17764086 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: HEANE" - "Source: Scopus" |
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