Systemic therapy for hepatocellular carcinoma: Cytotoxic chemotherapy, targeted therapy and immunotherapy Journal Article


Authors: Thomas, M. B.; O'Beirne, J. P.; Furuse, J.; Chan, A. T. C.; Abou-Alfa, G.; Johnson, P.
Article Title: Systemic therapy for hepatocellular carcinoma: Cytotoxic chemotherapy, targeted therapy and immunotherapy
Abstract: Conventional cytotoxic chemotherapy has not provided clinical benefit or prolonged survival for patients with advanced HCC. This review summarizes the results of prospective clinical trials of several categories of systemic therapy, with emphasis on the more promising results from recent trials of biologically targeted therapeutic agents in HCC. © 2007 Society of Surgical Oncology.
Keywords: mitogen activated protein kinase; protein kinase b; cancer chemotherapy; overall survival; thalidomide; clinical trial; drug activity; sorafenib; bevacizumab; cisplatin; cytotoxic agent; doxorubicin; erlotinib; fluorouracil; interferon; placebo; liver cell carcinoma; systemic therapy; antineoplastic agents; carcinoma, hepatocellular; clinical trials as topic; liver neoplasms; conference paper; drug targeting; capecitabine; gemcitabine; chemotherapy; dendritic cell; epidermal growth factor receptor; antineoplastic activity; cancer cell culture; drug resistance; cetuximab; phosphatidylinositol 3 kinase; transcription factors; panitumumab; drug delivery systems; clinical study; enzyme phosphorylation; immune response; immunotherapy; enzyme inhibitors; epigenetics; epigenesis, genetic; mammalian target of rapamycin; 1-phosphatidylinositol 3-kinase; comorbidity; gefitinib; protein farnesyltransferase inhibitor; tamoxifen; biologic therapy; dna topoisomerase (atp hydrolysing); oxaliplatin; mitogen-activated protein kinases; growth factor; clinical trials; correlational study; carcinogenic activity; growth inhibitors; hepatoma; chemoresistance; nolatrexed; hepatocellular; liver carcinogenesis; oncogene protein v-akt
Journal Title: Annals of Surgical Oncology
Volume: 15
Issue: 4
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2008-04-01
Start Page: 1008
End Page: 1014
Language: English
DOI: 10.1245/s10434-007-9705-0
PUBMED: 18236117
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 24" - "Export Date: 17 November 2011" - "CODEN: ASONF" - "Source: Scopus"
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  1. Ghassan Abou-Alfa
    568 Abou-Alfa