Liver-directed therapies for hepatocellular carcinoma and intrahepatic cholangiocarcinoma Journal Article


Authors: Kis, B.; El-Haddad, G.; Sheth, R. A.; Parikh, N. S.; Ganguli, S.; Shyn, P. B.; Choi, J.; Brown, K. T.
Article Title: Liver-directed therapies for hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Abstract: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC) are primary liver cancers where all or most of the tumor burden is usually confined to the liver. Therefore, locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease with minimal systemic side effects. The English medical literature and clinical trials were reviewed to provide a synopsis on the available liver-directed percutaneous therapies for HCC and IHC. Locoregional liver-directed therapies provide survival benefit for patients with HCC and IHC compared to best medical treatment and have lower comorbid risks compared to surgical resection. These treatment options should be considered, especially in patients with unresectable disease. © 2017, © The Author(s) 2017.
Keywords: hepatocellular carcinoma; chemoembolization; cholangiocarcinoma; percutaneous ablation; radioembolization
Journal Title: Cancer Control
Volume: 24
Issue: 3
ISSN: 1073-2748
Publisher: H. Lee Moffitt Cancer Center & Research Institute  
Date Published: 2017-09-01
Start Page: 1073274817729244
Language: English
DOI: 10.1177/1073274817729244
PROVIDER: scopus
PUBMED: 28975829
PMCID: PMC5937250
DOI/URL:
Notes: Review -- Export Date: 2 January 2018 -- Source: Scopus
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  1. Karen T Brown
    178 Brown