On the origins of clinical drug resistance Journal Article
| Authors: | O'Brien, J. P.; Cordon-Cardo, C. |
| Article Title: | On the origins of clinical drug resistance |
| Abstract: | Recent progress in understanding the clinical importance of certain laboratory models of drug resistance is cause for clinical oncologists to rethink some of the current concepts used in developing chemotherapy programs. The following discussion will reexamine a popular model of resistance development and highlight certain insights gained from clinical and laboratory studies of multidrug resistance. Such insights both challenge traditional concepts of cancer treatment and suggest new therapeutic approaches that would otherwise not have been apparent. © 1991 by W.B. Saunders Company. |
| Keywords: | cancer chemotherapy; genetics; review; antineoplastic agents; antineoplastic agent; neoplasm; neoplasms; mouse; animal; metabolism; mice; biological model; models, biological; drug resistance; physiology; gene expression regulation; gene expression regulation, neoplastic; membrane glycoproteins; membrane protein; multidrug resistance; p-glycoprotein; glycoprotein p; human; male; female; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Seminars in Cancer Biology |
| Volume: | 2 |
| Issue: | 4 |
| ISSN: | 1044-579X |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 1991-08-01 |
| Start Page: | 227 |
| End Page: | 233 |
| Language: | English |
| PUBMED: | 1680494 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
