Mathematical models of cancer stem cells Journal Article


Author: Michor, F.
Article Title: Mathematical models of cancer stem cells
Abstract: Human cancers are thought to be sustained in their growth by a pathologic counterpart of normal adult stem cells: cancer stem cells. This concept was first developed in human myeloid leukemias and is today being extended to solid tumors such as breast and brain cancers. A quantitative understanding of cancer stem cells requires a mathematical framework to describe the dynamics of cancer initiation and progression, the response to treatment, and the evolution of resistance. In this review, I use chronic myeloid leukemia as an example to discuss how mathematical and computational techniques have been used to gain insights into the biology of cancer stem cells. © 2008 by American Society of Clinical Oncology.
Keywords: treatment response; treatment failure; gene mutation; genetics; mutation; review; cancer growth; drug withdrawal; nonhuman; patient selection; unspecified side effect; antineoplastic agents; alpha interferon; cytarabine; antineoplastic agent; cell proliferation; cytology; cell survival; imatinib; breast cancer; biological model; models, biological; protein kinase inhibitor; cell differentiation; drug effect; drug resistance; pathology; drug resistance, neoplasm; cell population; chronic myeloid leukemia; pyrimidines; time; time factors; carcinogenesis; cancer resistance; mathematical model; protein kinase inhibitors; gene expression regulation; oncogene; bone marrow biopsy; neoplastic stem cells; leukemia cell; cancer stem cell; irradiation; cell count; brain cancer; real time polymerase chain reaction; hematopoietic stem cell; bcr abl protein; piperazines; point mutation; piperazine derivative; pyrimidine derivative; beta catenin; leukemia, myelogenous, chronic, bcr-abl positive; mathematical computing; philadelphia 1 chromosome; gene expression regulation, leukemic; blast cell crisis; philadelphia chromosome positive cell
Journal Title: Journal of Clinical Oncology
Volume: 26
Issue: 17
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2008-06-10
Start Page: 2854
End Page: 2861
Language: English
DOI: 10.1200/jco.2007.15.2421
PUBMED: 18539964
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 19" - "Export Date: 17 November 2011" - "CODEN: JCOND" - "Source: Scopus"
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  1. Franziska Michor
    23 Michor