Mathematical models of cancer stem cells Journal Article
| Author: | Michor, F. |
| Article Title: | Mathematical models of cancer stem cells |
| Abstract: | Human cancers are thought to be sustained in their growth by a pathologic counterpart of normal adult stem cells: cancer stem cells. This concept was first developed in human myeloid leukemias and is today being extended to solid tumors such as breast and brain cancers. A quantitative understanding of cancer stem cells requires a mathematical framework to describe the dynamics of cancer initiation and progression, the response to treatment, and the evolution of resistance. In this review, I use chronic myeloid leukemia as an example to discuss how mathematical and computational techniques have been used to gain insights into the biology of cancer stem cells. © 2008 by American Society of Clinical Oncology. |
| Keywords: | treatment response; treatment failure; gene mutation; genetics; mutation; review; cancer growth; drug withdrawal; nonhuman; patient selection; unspecified side effect; antineoplastic agents; alpha interferon; cytarabine; antineoplastic agent; cell proliferation; cytology; cell survival; imatinib; breast cancer; biological model; models, biological; protein kinase inhibitor; cell differentiation; drug effect; drug resistance; pathology; drug resistance, neoplasm; cell population; chronic myeloid leukemia; pyrimidines; time; time factors; carcinogenesis; cancer resistance; mathematical model; protein kinase inhibitors; gene expression regulation; oncogene; bone marrow biopsy; neoplastic stem cells; leukemia cell; cancer stem cell; irradiation; cell count; brain cancer; real time polymerase chain reaction; hematopoietic stem cell; bcr abl protein; piperazines; point mutation; piperazine derivative; pyrimidine derivative; beta catenin; leukemia, myelogenous, chronic, bcr-abl positive; mathematical computing; philadelphia 1 chromosome; gene expression regulation, leukemic; blast cell crisis; philadelphia chromosome positive cell |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 26 |
| Issue: | 17 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2008-06-10 |
| Start Page: | 2854 |
| End Page: | 2861 |
| Language: | English |
| DOI: | 10.1200/jco.2007.15.2421 |
| PUBMED: | 18539964 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 19" - "Export Date: 17 November 2011" - "CODEN: JCOND" - "Source: Scopus" |
