Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade Journal Article
| Authors: | De Silva, D. L.; Luo, J. |
| Article Title: | Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade |
| Abstract: | PD-1 blockade is now routine for nearly all patients with non-small lung cancer. Acquired resistance to PD-1 blockade - defined generally as an initial response followed later by progression [1-3] is a common yet poorly understood concept. A key clinical challenge to insight has been a lack of standard guidance for clinical management of a case of suspected acquired resistance. The infrequency of performing tumor biopsies and the uncertainty of actionability from tissue sampling likely also contribute to limited insight into the biology of acquired resistance [4]. To address this knowledge gap and to highlight the value of tumor and liquid biopsy, we present a representative case of suspected acquired resistance to PD-1 blockade and propose a multi-modal guide for approaching this clinical scenario. © 2024 The Authors. |
| Keywords: | clinical article; human tissue; protein expression; unclassified drug; gene mutation; sequence analysis; case report; carboplatin; computer assisted tomography; multiple cycle treatment; mitogen activated protein kinase kinase 2; maintenance therapy; protein p53; tumor marker; distant metastasis; lung adenocarcinoma; immunotherapy; therapy resistance; biopsy technique; receptor blocking; pemetrexed; non-small cell lung cancer; personalized medicine; lung nodule; programmed death 1 receptor; non small cell lung cancer; tissue biopsy; granulomatous inflammation; maximum standardized uptake value; kelch like ech associated protein 1; human; article; precision medicine; pembrolizumab; positron emission mammography; pd-1 blockade; liquid biopsy; current smoker; acquired resistance to immunotherapy; molecular sequencing; at rich interactive domain-containing protein 1a; transcription activator brg1; bilateral lung nodules; metastatic lung adenocarcinoma; necrotizing granulomatous inflammation.; programmed death 1 receptor blockade; subpleural nodule in the lingula; tissue sequencing |
| Journal Title: | Future Science OA |
| Volume: | 10 |
| Issue: | 1 |
| ISSN: | 2056-5623 |
| Publisher: | Future Science Ltd. |
| Date Published: | 2024-01-01 |
| Start Page: | FSO937 |
| Language: | English |
| DOI: | 10.2144/fsoa-2023-0010 |
| PROVIDER: | scopus |
| PMCID: | PMC11137779 |
| PUBMED: | 38817357 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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