Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration Journal Article

   


Authors: Fathallah-Shaykh, H.; Wolf, S.; Wong, E.; Posner, J. B.; Furneaux, H. M.
Article Title: Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration
Abstract: Antibody-associated paraneoplastic cerebellar degeneration (the Yo syndrome) is an uncommon disorder in which an immune response is specifically directed against tumor tissue and the cerebellum. Screening of a A expression library has resulted in the isolation of cDNA clones that encode the major antigen recognized by serum from these patients. The fusion protein produced by the cDNA clones provides the basis of a simple diagnostic assay for this neurological syndrome. The occurrence of leucine-zipper and zinc-finger motifs in the predicted open reading frame suggests that this protein plays a role in the regulation of gene expression.
Keywords: human cell; dna-binding proteins; neoplasm proteins; tumor antigen; gene expression regulation; cloning, molecular; blotting, western; amino acid sequence; molecular sequence data; antigen; recombinant fusion proteins; rna, messenger; molecular recognition; tumor antigens; autoantigens; enzyme-linked immunosorbent assay; blotting, northern; autoantibodies; leucine zipper protein; cerebellar diseases; paraneoplastic syndromes; cerebellum degeneration; human; priority journal; article; leucine zippers; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s.; neurological syndrome; remote effects of cancer
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 88
Issue: 8
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 1991-04-15
Start Page: 3451
End Page: 3454
Language: English
DOI: 10.1073/pnas.88.8.3451
PUBMED: 2014264
PROVIDER: scopus
PMCID: PMC51465
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026335993&doi=10.1073%2fpnas.88.8.3451&partnerID=40&md5=29547dd370aaa224e9bc47429df5bd8b
Notes: Source: Scopus
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MSK Authors
  1. Henry M Furneaux
    57 Furneaux
  2. Jerome B Posner
    211 Posner
  3. Ellen Wong
    14 Wong
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