Differences in human immunodeficiency virus type 1 (HIV-1) anti-p24 reactivities in serum of HIV-1-infected and uninfected subjects: Analysis of indeterminate Western blot reactions Journal Article

  

Authors:	Povolotsky, J.; Gold, J. W. M.; Chein, N.; Baron, P.; Armstrong, D.
Article Title:	Differences in human immunodeficiency virus type 1 (HIV-1) anti-p24 reactivities in serum of HIV-1-infected and uninfected subjects: Analysis of indeterminate Western blot reactions
Abstract:	Anti-p24 reactions in sera from 42 human immunodeficiency virus type 1 (HIV-l)-infected and 36 uninfected people with indeterminate Western blot antibody tests for HIV-l were studied. Anti-p24 reactivity in HIV-l-infected people was completely blocked by HIV-l recombinant p24 antigen, whereas the reaction in uninfected individuals with indeterminate patterns was inhibited partly or not at all. In contrast to infected individuals, anti-p24 reactivity from uninfected individuals could not bedetected by an inhibition ELISA for HIV-l p24 antibody. These results suggest a practical way to distinguish anti-p24 reactivity in sera from patients with HIV-l infection from that seen in uninfected patients with indeterminate Western blot reactions. © 1991 by The University of Chicago.
Keywords:	adult; clinical article; controlled study; human immunodeficiency virus infection; enzyme linked immunosorbent assay; blotting, western; immunoblotting; antibody specificity; virus antigen; human immunodeficiency virus; enzyme-linked immunosorbent assay; antibody detection; hiv infections; antibody titer; hiv-1; lymphocyte subpopulation; virus culture; gene products, gag; hiv antibodies; human; priority journal; article; hiv antigens; viral core proteins; hiv core protein p24
Journal Title:	Journal of Infectious Diseases
Volume:	163
Issue:	2
ISSN:	0022-1899
Publisher:	Oxford University Press
Date Published:	1991-02-01
Start Page:	247
End Page:	251
Language:	English
DOI:	10.1093/infdis/163.2.247
PUBMED:	1899100
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026031080&doi=10.1093%2finfdis%2f163.2.247&partnerID=40&md5=e3c6e60d8efb38566907ca2ba9fc70dc
Notes:	Article -- Export Date: 27 September 2019 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/154511