Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor Journal Article
| Authors: | Marino, M. W.; Feld, L. J.; Jaffe, E. A.; Pfeffer, L. M.; Han, H. M.; Donner, D. B. |
| Article Title: | Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor |
| Abstract: | The initiation of mRNA translation is regulated by the reversible phosphorylation of several initiation factors. We report here that tumor necrosis factor-α (TNF) rapidly stimulates phosphorylation of one such factor, an mRNA cap binding protein, in several cell types which are important in vitro models of TNF action. This protein has been purified, sequenced, and identified as the proto-oncogene product eukaryotic initiation factor 4E. These data show that phosphorylation of a key component of the cellular translational machinery is a common early event in the various actions of TNF in diverse cell types. |
| Keywords: | protein phosphorylation; human cell; proto-oncogene proteins; proto oncogene; tumor cells, cultured; phosphorylation; rna binding protein; amino acid sequence; molecular sequence data; tumor necrosis factor alpha; rna, messenger; rna translation; chromatography, high pressure liquid; autoradiography; electrophoresis, polyacrylamide gel; tumor necrosis factor; eukaryotic initiation factor-4e; initiation factor; peptide initiation factors; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; translation, genetic |
| Journal Title: | Journal of Biological Chemistry |
| Volume: | 266 |
| Issue: | 5 |
| ISSN: | 0021-9258 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Date Published: | 1991-02-15 |
| Start Page: | 2685 |
| End Page: | 2688 |
| Language: | English |
| PUBMED: | 1993647 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
