High‐dose cisplatin plus dacarbazine in the treatment of metastatic melanoma Journal Article
| Authors: | Murren, J. R.; DeRosa, W.; Durivage, H. J.; Davis, C.; Makuch, R.; Portlock, C. S. |
| Article Title: | High‐dose cisplatin plus dacarbazine in the treatment of metastatic melanoma |
| Abstract: | The combination of cisplatin plus dacarbazine (DTIC) is active in metastatic melanoma with response rates reported between 10% and 55%. To optimize this regimen, a Phase II study was conducted employing a dose intensity of cisplatin higher than previously reported. Twenty‐two patients were treated. Eight patients received cisplatin 100 mg/m2 on days 1 and 8 combined with DTIC 300 mg/m2 on days 1, 2, 8, and 9 (regimen A). Because of excessive toxicity, the protocol was modified so that cisplatin was given at 50 mg/m2 per day and DTIC 350 mg/m2 per day on days 1 through 3 (regimen B). The overall response rate was 32% and consisted of four partial and three complete responses (CR). The median duration of response was 6 months. Two of the CR remain in sustained, unmaintained remission in excess of 1.5 years. All seven patients that responded were treated on regimen B. High‐dose cisplatin plus DTIC on a 3‐day schedule represents an effective, well‐tolerated therapy for metastatic melanoma. Copyright © 1991 American Cancer Society |
| Keywords: | adult; clinical article; aged; survival rate; cisplatin; dacarbazine; melanoma; metastasis; nephrotoxicity; phase 2 clinical trial; bone marrow suppression; antineoplastic combined chemotherapy protocols; animal experiment; drug response; remission induction; intravenous drug administration; hematologic diseases; middle age; nervous system diseases; drug evaluation; kidney diseases; human; male; female; priority journal; article |
| Journal Title: | Cancer |
| Volume: | 67 |
| Issue: | 6 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1991-03-15 |
| Start Page: | 1514 |
| End Page: | 1517 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19910315)67:6<1514::Aid-cncr2820670609>3.0.Co;2-q |
| PUBMED: | 2001539 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
