Trial of the combination of mitomycin, vindesine, and cisplatin in patients with advanced non-small cell lung cancer Journal Article
| Authors: | Kris, M. G.; Gralla, R. J.; Wertheim, M. S.; Kelsen, D. P.; O'Connell, J. P.; Burke, M. T.; Fiore, J. J.; Cibas, I. R.; Heelan, R. T. |
| Article Title: | Trial of the combination of mitomycin, vindesine, and cisplatin in patients with advanced non-small cell lung cancer |
| Abstract: | In prior trials, mitomycin, vindesine, and cisplatin have each been shown to have reproducible antitumor activity as single agents when used in the treatment of patients with non-small cell lung cancer. The two-drug combinations of vindesine plus high-dose cisplatin or mitomycin have shown an improved major response rate and manageable toxicity in prior trials. In this report, 90 patients with stage III non-small cell lung cancer were treated with the three-drug combination of mitomycin (8 mg/m2), vindesine (3 mg/m2), and high-dose cisplatin (120 mg/m2). Eighty-seven patients (97%) were adequate for both response and toxicity. Major objective responses occurred in 60% of the patients. The toxicity of this regimen was predictable and manageable when established supportive care measures were employed. Based on the response rate observed, the combination of these three agents merits further study in randomized trials against other chemotherapeutic regimens and consideration of its use in adjuvant and preoperative settings. |
| Keywords: | cancer chemotherapy; middle aged; major clinical study; cisplatin; cancer combination chemotherapy; drug efficacy; neurotoxicity; follow-up studies; nephrotoxicity; antineoplastic combined chemotherapy protocols; lung neoplasms; peripheral neuropathy; lorazepam; lung cancer; dexamethasone; kidney; carcinoma; neoplasm metastasis; vindesine; drug toxicity; drug therapy; mitomycin; metoclopramide; mannitol; adverse drug reaction; therapy; clinical trials; intravenous drug administration; diphenhydramine; nervous system; bone marrow depression; intoxication; respiratory system; drug mixture; mitomycins; humans; human; male; female; priority journal; blood and hemopoietic system |
| Journal Title: | Cancer Treatment Reports |
| Volume: | 70 |
| Issue: | 9 |
| ISSN: | 0361-5960 |
| Publisher: | National Cancer Institute |
| Date Published: | 1986-09-01 |
| Start Page: | 1091 |
| End Page: | 1096 |
| Language: | English |
| PUBMED: | 3527408 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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