Pneumocystis carinii pneumonia in patients with primary brain tumors Journal Article

  


Authors: Henson, J. W.; Jalaj, J. K.; Walker, R. W.; Stover, D. E.; Fels, A. O. S.
Article Title: Pneumocystis carinii pneumonia in patients with primary brain tumors
Abstract: All histologically documented episodes of Pneumocystis carinii pneumonia in adult patients with primary brain tumors treated at Memorial Sloan-Kettering Cancer Center, New York, NY, since 1981, were retrospectively reviewed. Pneumocystis carinii pneumonia was histologically documented 11 times in 10 patients. During the same 8-year interval, approximately 587 adults were seen at the center for a brain tumor, 90% of whom received ongoing therapy. Therefore, in at least 1.7% (10/587) of our patients with brain tumors, P carinii pneumonia developed. The median duration of dexamethasone therapy at the onset of P carinii pneumonia symptoms was 2.75 months. Symptoms began during tapering of steroid therapy in eight episodes. Bronchoscopy was diagnostic in the eight cases in which it was performed. Four episodes (40%) were fatal. Trimethoprim-sulfamethoxazole prophylaxis may be indicated in some patients with brain tumors, especially during tapering of steroid therapy. © 1991, American Medical Association. All rights reserved.
Keywords: adult; clinical article; human tissue; antibiotic agent; retrospective studies; hydroxyurea; fluorouracil; brain tumor; brain neoplasms; antineoplastic agent; dexamethasone; vincristine; pneumocystis pneumonia; carmustine; chlormethine; lomustine; procarbazine; bronchoscopy; misonidazole; corticosteroid; opportunistic infections; sulfamethoxazole; trimethoprim; trimethoprim-sulfamethoxazole combination; 1 (2 chloroethyl) 3 (2,6 dioxo 3 piperidyl) 1 nitrosourea; human; priority journal; article; pneumonia, pneumocystis carinii
Journal Title: Archives of Neurology
Volume: 48
Issue: 4
ISSN: 0003-9942
Publisher: American Medical Association  
Date Published: 1991-04-01
Start Page: 406
End Page: 409
Language: English
DOI: 10.1001/archneur.1991.00530160074017
PUBMED: 2012515
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025761357&doi=10.1001%2farchneur.1991.00530160074017&partnerID=40&md5=8742973fcf0b52b61c9cebcaa290dec0
Notes: Article -- Source: Scopus
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  1. Diane E Stover-Pepe
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  2. Russell W. Walker
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