Bacterial pneumonia in patients with the acquired immunodeficiency syndrome Journal Article

  


Authors: Polsky, B.; Gold, J. W. M.; Whimbey, E.; Dryjanski, J.; Brown, A. E.; Schiffman, G.; Armstrong, D.
Article Title: Bacterial pneumonia in patients with the acquired immunodeficiency syndrome
Abstract: Eighteen episodes of community-acquired bacterial pneumonia were diagnosed in 13 patients among 336 with the acquired immunodeficiency syndrome (AIDS) cared for at Memorial Sloan-Kettering Cancer Center since 1979. Bacterial pathogens isolated in 16 of 18 episodes were Haemophilus influenzae in 8, Streptococcus pneumoniae in 6, group B streptococcus in 1, and Branhamella catarrhalis in 1. Eight episodes were presumed Pneumocystis carinii pneumonia until cultures obtained at bronchoscopy confirmed a bacterial cause. Specific antibacterial therapy was curative in 16 of 18 episodes; 2 patients died. Given an estimated yearly incidence of pneumococcal pneumonia in the general population of 2.6/1,000, 1.09 cases were expected in our patients with AIDS; we saw 6 (p = 0.001), for an attack rate of 17.9/1,000. Bacteria associated with B-cell defects should be anticipated when formulating empiric antibiotic therapy, pending a definitive diagnosis, for pulmonary infiltrates in patients with AIDS.
Keywords: clinical article; drug efficacy; b lymphocyte; pneumonia; diagnosis; bronchoscopy; acquired immune deficiency syndrome; epidemiology; drug therapy; cotrimoxazole; streptococcus pneumoniae; therapy; erythromycin; ampicillin; respiratory system; haemophilus influenzae; pneumocystis carinii; penicillin g; human; priority journal; pentamidine isethionate; blood and hemopoietic system; cefamandole; moraxella catarrhalis
Journal Title: Annals of Internal Medicine
Volume: 104
Issue: 1
ISSN: 0003-4819
Publisher: American College of Physicians  
Date Published: 1986-01-01
Start Page: 38
End Page: 41
Language: English
DOI: 10.7326/0003-4819-104-1-38
PROVIDER: scopus
PUBMED: 3484420
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022648533&doi=10.7326%2f0003-4819-104-1-38&partnerID=40&md5=e21e71a03015a64ee0078a9d1a206099
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors thank Dr. James Godbold of the Biostatistics Laboratory of MSK for statistical analysis
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Bruce Polsky
    69 Polsky
  2. Arthur E Brown
    76 Brown
  3. Donald Armstrong
    240 Armstrong
  4. Jonathan W. M. Gold
    73 Gold
Related MSK Work