Bacterial pneumonia in patients with the acquired immunodeficiency syndrome Journal Article


Authors: Polsky, B.; Gold, J. W. M.; Whimbey, E.; Dryjanski, J.; Brown, A. E.; Schiffman, G.; Armstrong, D.
Article Title: Bacterial pneumonia in patients with the acquired immunodeficiency syndrome
Abstract: Eighteen episodes of community-acquired bacterial pneumonia were diagnosed in 13 patients among 336 with the acquired immunodeficiency syndrome (AIDS) cared for at Memorial Sloan-Kettering Cancer Center since 1979. Bacterial pathogens isolated in 16 of 18 episodes were Haemophilus influenzae in 8, Streptococcus pneumoniae in 6, group B streptococcus in 1, and Branhamella catarrhalis in 1. Eight episodes were presumed Pneumocystis carinii pneumonia until cultures obtained at bronchoscopy confirmed a bacterial cause. Specific antibacterial therapy was curative in 16 of 18 episodes; 2 patients died. Given an estimated yearly incidence of pneumococcal pneumonia in the general population of 2.6/1,000, 1.09 cases were expected in our patients with AIDS; we saw 6 (p = 0.001), for an attack rate of 17.9/1,000. Bacteria associated with B-cell defects should be anticipated when formulating empiric antibiotic therapy, pending a definitive diagnosis, for pulmonary infiltrates in patients with AIDS.
Keywords: clinical article; drug efficacy; b lymphocyte; pneumonia; diagnosis; bronchoscopy; acquired immune deficiency syndrome; epidemiology; drug therapy; cotrimoxazole; streptococcus pneumoniae; therapy; erythromycin; ampicillin; respiratory system; haemophilus influenzae; pneumocystis carinii; penicillin g; human; priority journal; pentamidine isethionate; blood and hemopoietic system; cefamandole; moraxella catarrhalis
Journal Title: Annals of Internal Medicine
Volume: 104
Issue: 1
ISSN: 0003-4819
Publisher: American College of Physicians  
Date Published: 1986-01-01
Start Page: 38
End Page: 41
Language: English
DOI: 10.7326/0003-4819-104-1-38
PROVIDER: scopus
PUBMED: 3484420
DOI/URL:
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors thank Dr. James Godbold of the Biostatistics Laboratory of MSK for statistical analysis
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MSK Authors
  1. Bruce Polsky
    68 Polsky
  2. Arthur E Brown
    73 Brown
  3. Donald Armstrong
    226 Armstrong
  4. Jonathan W. M. Gold
    64 Gold