Role of imaging in low-grade cutaneous B-cell lymphoma presenting in the skin Journal Article


Authors: Kheterpal, M. K.; Dai, J.; Geller, S.; Pulitzer, M.; Ni, A.; Myskowski, P. L.; Moskowitz, A.; Kim, J.; Hong, E. K.; Fong, S.; Hoppe, R. T.; Kim, Y. H.; Horwitz, S. M.
Article Title: Role of imaging in low-grade cutaneous B-cell lymphoma presenting in the skin
Abstract: Background: Whole-body imaging is the current standard of care for staging all patients presenting with skin lesions of B-cell lymphomas (BCLs), regardless of skin disease extent; however, supporting data are lacking. Objective: To determine the clinical utility of imaging in the detection of systemic involvement in low-grade cutaneous BCLs in the skin. Methods: Retrospective cohort analysis of patients presenting with cutaneous lesions of BCLs at Memorial Sloan Kettering Cancer Center and Stanford University during 1997-2016. Results: At initial staging, of the 522 patients, extracutaneous disease was noted in 3.6% and 8.8% of patients with marginal zone lymphoma (MZL, n = 306) and follicle center lymphoma (FCL, n = 216) histology, respectively. In patients with systemic involvement, imaging alone identified 81.8% (9/11) of MZL cases and 89.4% of follicular lymphoma cases. In primary cutaneous MZL, 1.7% of patients subsequently had extracutaneous involvement (median follow-up 45 months), and in primary cutaneous FCL. 3.0% subsequently had extracutaneous involvement (median follow-up 47 months). Limitations: This was a retrospective study. Conclusion: Imaging is effective at identifying patients with systemic involvement in indolent BCLs present in the skin; however, incidence is low. After negative initial staging, primary cutaneous MZL patients may be followed clinically without routine imaging. © 2019 American Academy of Dermatology, Inc.
Keywords: imaging; primary cutaneous b-cell lymphoma; prognosis; systemic involvement of cutaneous b-cell lymphoma
Journal Title: Journal of the American Academy of Dermatology
Volume: 81
Issue: 4
ISSN: 0190-9622
Publisher: Mosby Elsevier  
Date Published: 2019-10-01
Start Page: 970
End Page: 976
Language: English
DOI: 10.1016/j.jaad.2019.01.037
PUBMED: 30703460
PROVIDER: scopus
PMCID: PMC6661219
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Melissa P Pulitzer
    158 Pulitzer
  2. Steven M Horwitz
    486 Horwitz
  3. Alison Moskowitz
    228 Moskowitz
  4. Patricia Myskowski
    196 Myskowski
  5. Ai   Ni
    96 Ni
  6. Shamir Geller
    37 Geller