Low-grade cutaneous B-cell lymphoma in African American patients Journal Article

Authors: Geller, S.; Pulitzer, M.; Myskowski, P. L.; Kheterpal, M.
Article Title: Low-grade cutaneous B-cell lymphoma in African American patients
Abstract: Introduction: Cutaneous marginal zone lymphoma (CMZL) and cutaneous follicle center lymphoma (CFCL) are rare indolent cutaneous B-cell lymphomas (CBCL). Their incidence in African American (AA) patients is extremely low. While cutaneous T-cell lymphomas appear to be more aggressive in AA individuals, there is no data on the presentation and course of disease of CBCL in this group. In this study, we aimed to characterize CMZL/CFCL in AA patients. Methods: A retrospective chart review identified 10 AA patients with CMZL/CFCL. We compared demographics, clinical features, and systemic disease incidence between AA and white patients. Results: Of 288 patients with CMZL/CFCL, 10 patients were AA (3.5%), and 266 were white. AA patients trended toward diagnosis at a younger age compared to white individuals (median age of 41 vs 54 years; P=0.07). AAs presented with more regional and generalized cutaneous disease (T2-T3 in 70%), while most white patients presented with a solitary lesion (T1 in 55%). Head and neck involvement was more common in AA patients. Extracutaneous systemic disease at initial staging was not significantly different between the groups. One AA patient with primary CMZL developed extracutaneous MZL after 16 years. No deaths were reported among AAs. Discussion: CMZL/CFCL in this series of AA patients had an earlier age of onset with preferential head and neck involvement and a higher T classification at presentation. Despite these features, systemic involvement was uncommon, and no deaths were recorded. This data supports an indolent course of CMZL and CFCL in the AA population; larger studies are needed to confirm these findings.
Keywords: classification; trends; united-states; mycosis-fungoides; treatment-of-cancer; prognosis
Journal Title: Journal of Drugs in Dermatology
Volume: 17
Issue: 12
ISSN: 1545-9616
Publisher: Journal of Drugs in Dermatology, Inc.  
Date Published: 2018-12-01
Start Page: 1334
End Page: 1337
Language: English
ACCESSION: WOS:000453941400012
PUBMED: 30586269
Notes: Source: Wos
Citation Impact
MSK Authors
  1. Melissa P Pulitzer
    158 Pulitzer
  2. Patricia Myskowski
    196 Myskowski
  3. Shamir Geller
    37 Geller