Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features and diagnosis Review
| Authors: | Stoll, J. R.; Willner, J.; Oh, Y.; Pulitzer, M.; Moskowitz, A.; Horwitz, S.; Myskowski, P.; Noor, S. J. |
| Review Title: | Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features and diagnosis |
| Abstract: | Primary cutaneous T-cell lymphomas (CTCLs) are defined as lymphomas with a T-cell phenotype that present in the skin without evidence of systemic or extracutaneous disease at initial presentation. CTCLs other than mycosis fungoides and S = ezary syndrome (SS) account for approximately one third of CTCLs and encompass a heterogenous group of non-Hodgkin lymphomas, ranging from indolent lymphoproliferative disorders to aggressive malignancies with a poor prognosis. The spectrum of CTCLs continues to broaden as new provisional entities are classified. Given the morphologic and histologic overlap among CTCLs and other diagnoses, a thorough clinical history, physical evaluation, and clinicopathologic correlation are essential in the work up and diagnosis of these rare entities. This article will summarize the epidemiologic, clinical, pathologic, and diagnostic features of CTCLs other than mycosis fungoides and SS. ( J Am Acad Dermatol 2021;85:1073-90.) |
| Keywords: | lymphoma; subcutaneous; t-cell lymphoma; mycosis fungoides; lymphoproliferative disorders; primary; term-follow-up; clinicopathological features; peripheral t-cell lymphoma; sezary syndrome; differential-diagnosis; small; lymphomatoid papulosis; natural; panniculitis-like t-cell lymphoma; not otherwise specified; health-organization classification; nasal type; cutaneous t-cell; primary cutaneous; cd30(+) lymphoproliferative disorders; retrospective case series; cutaneous gamma-delta t-cell lymphoma; histopathologic features; adult t-cell leukemia; adult t-cell lymphoma; angioimmunoblastic t-cell; cytotoxic primary cutaneous anaplastic large cell lymphoma; extranodal nk; primary cutaneous acral cd8(+ )t-cell lymphoma; primary cutaneous cd4(+); medium t-cell lymphoproliferative disorder; cd8(+) aggressive epidermotropic cytotoxic t-cell lymphoma; killer/t-cell; nk/t-cell; acral sites |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 85 |
| Issue: | 5 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2021-11-01 |
| Start Page: | 1073 |
| End Page: | 1090 |
| Language: | English |
| ACCESSION: | WOS:000709866200021 |
| DOI: | 10.1016/j.jaad.2021.04.080 |
| PROVIDER: | wos |
| PUBMED: | 33940098 |
| Notes: | Article -- for Part II, see https://synapse.mskcc.org/synapse/works/188823 -- Source: Wos |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work