New 5'-phosphonates of dugar-modified nucleosides as inhibitors of HIV production Journal Article
| Authors: | Krayevsky, A.; Tarussova, N.; Zhu, Q. Y.; Vidal, P.; Chou, T. C.; Baron, P.; Polsky, B.; Jiang, X. J.; Matulic-Adamic, J.; Rosenberg, I.; Watanabe, K. A. |
| Article Title: | New 5'-phosphonates of dugar-modified nucleosides as inhibitors of HIV production |
| Abstract: | A number of nucleoside 5'-H-phosphonates (nucleoside 5'-phosphites) and nucleoside 5'-methylphosphonates were synthesized, and their ability to inhibit the production of human immunodeficiency virus (HIV) in cell cultures was studied. Three compounds, the 5'-H-phosphonates of 3'-azido-2',3'-dideoxythymidine,* 3'-fluoro-2', 3'-dideoxythymidine, and 2' 3'-dideoxyadenosine, exhibited high activity with selectivity close to or higher than that of the corresponding nucleosides. |
| Keywords: | human-immunodeficiency-virus; analogs; activity; potent; dna-polymerases; infectivity; iii/lymphadenopathy-associated virus; 3'-substituted 2',3'-dideoxynucleoside; selective invitro; htlv-iii/lav agents; 3'-deoxythymidin-2'-ene; 3'-deoxy-2',3'-didehydrothymidine |
| Journal Title: | Molecular Biology |
| Volume: | 26 |
| Issue: | 3 |
| ISSN: | 0026-8933 |
| Publisher: | Pleiades Publishing, Inc |
| Date Published: | 1992-01-01 |
| Start Page: | 481 |
| End Page: | 489 |
| Language: | English |
| ACCESSION: | WOS:A1992KF44600008 |
| PROVIDER: | wos |
| Notes: | Article -- Translated from Molekulyarnaya Biologiya, Vol. 26, No. 3, pp. 624-634, May-June 1992 -- Source: Wos |
