Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes Journal Article

  


Authors: Savage, P. A.; Vosseller, K.; Kang, C.; Larimore, K.; Riedel, E.; Wojnoonski, K.; Jungbluth, A. A.; Allison, J. P.
Article Title: Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes
Abstract: Substantial evidence exists that many tumors can be specifically recognized by CD8+ T lymphocytes. The definition of antigens targeted by these cells is paramount for the development of effective immunotherapeutic strategies for treating human cancers. In a screen for endogenous tumor-associated T cell responses in a primary mouse model of prostatic adenocarcinoma, we identified a naturally arising CD8+ T cell response that is reactive to a peptide derived from histone H4. Despite the ubiquitous nature of histones, T cell recognition of histone H4 peptide was specifically associated with the presence of prostate cancer in these mice. Thus, the repertoire of antigens recognized by tumor-infiltrating T cells is broader than previously thought and includes peptides derived from ubiquitous self antigens that are normally sequestered from immune detection.
Keywords: treatment response; nonhuman; polymerase chain reaction; adenocarcinoma; antigen expression; cd8+ t lymphocyte; tumor associated leukocyte; cd8-positive t-lymphocytes; lymphocytes, tumor-infiltrating; cytology; animals; mice; mus; cell line; mice, transgenic; prostate cancer; prostatic neoplasms; t lymphocyte receptor; t lymphocyte receptor beta chain; antigen presentation; amino acid sequence; antigen; immunotherapy; antigens, neoplasm; molecular recognition; major histocompatibility antigen class 2; antigen recognition; peptide fragments; autoantigens; adoptive transfer; prostate adenocarcinoma; immunity; lymphocytic infiltration; tumor; major histocompatibility complex; recognition; epitopes, t-lymphocyte; histones; receptors, antigen, t-cell, alpha-beta; t lymphocyte receptor alpha chain; histone h4; lymphocyte subpopulation; hybridomas; immunodetection; detection method; reproductive disorder; complementarity determining region
Journal Title: Science
Volume: 319
Issue: 5860
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2008-01-11
Start Page: 215
End Page: 220
Language: English
DOI: 10.1126/science.1148886
PUBMED: 18187659
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-38149035080&partnerID=40&md5=823c6fdd21c91ad61522a237bdacd35b
Notes: --- - "Cited By (since 1996): 32" - "Export Date: 17 November 2011" - "CODEN: SCIEA" - "Source: Scopus"
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MSK Authors
  1. Elyn Renee Stubblefield
    203 Stubblefield
  2. Peter A Savage
    3 Savage
  3. James P Allison
    130 Allison
  4. Achim Jungbluth
    458 Jungbluth
  5. Kathleen Wojnoonski
    2 Wojnoonski
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