Polysialic acid in the plasticity of the developing and adult vertebrate nervous system Journal Article

  


Author: Rutishauser, U.
Article Title: Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
Abstract: Polysialic acid (PSA) is a cell-surface glycan with an enormous hydrated volume that serves to modulate the distance between cells. This regulation has direct effects on several cellular mechanisms that underlie the formation of the vertebrate nervous system, most conspicuously in the migration and differentiation of progenitor cells and the growth and targeting of axons. PSA is also involved in a number of plasticity-related responses in the adult CNS, including changes in circadian and hormonal patterns, adaptations to pain and stress, and aspects of learning and memory. The ability of PSA to increase the plasticity of neural cells is being exploited to improve the repair of adult CNS tissue. © 2008 Nature Publishing Group.
Keywords: review; nonhuman; animals; pain; cell differentiation; central nervous system; stem cell; vertebrata; nerve fiber; nerve cell adhesion molecule; polysialic acid; nerve cell plasticity; cell migration; cell movement; glia cell; stem cells; stress; memory; cell interaction; neurologic disease; vertebrate; vertebrates; innervation; cell activity; axons; tissue repair; myelination; embryonic development; sialic acids; learning; neuronal plasticity; nervous system; hormone release; synapse; neural cell adhesion molecules; nerve growth; sialylation; circadian rhythm; nerve fiber regeneration; neurotrophin; visual system
Journal Title: Nature Reviews Neuroscience
Volume: 9
Issue: 1
ISSN: 1471-003X
Publisher: Nature Publishing Group  
Date Published: 2008-01-01
Start Page: 26
End Page: 35
Language: English
DOI: 10.1038/nrn2285
PUBMED: 18059411
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-37349120002&partnerID=40&md5=dbb72def6dd0a8908ca6e9efc621405d
Notes: --- - "Cited By (since 1996): 124" - "Export Date: 17 November 2011" - "CODEN: NRNAA" - "Source: Scopus"
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  1. Urs S Rutishauser
    70 Rutishauser
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