Visualizing new dimensions in Drosophila myoblast fusion Journal Article
| Authors: | Richardson, B.; Beckett, K.; Baylies, M. |
| Article Title: | Visualizing new dimensions in Drosophila myoblast fusion |
| Abstract: | Over several years, genetic studies in the model system, Drosophila melanogaster, have uncovered genes that when mutated, lead to a block in myoblast fusion. Analyses of these gene products have suggested that Arp2/3-mediated regulation of the actin cytoskeleton is crucial to myoblast fusion in the fly. Recent advances in imaging in Drosophila embryos, both in fixed and live preparations, have led to a new appreciation of both the three-dimensional organization of the somatic mesoderm and the cell biology underlying myoblast fusion. © 2008 Wiley Periodicals, Inc. |
| Keywords: | controlled study; gene mutation; review; nonhuman; protein function; animal cell; animals; actin; cell function; models, biological; embryo; gene product; gene expression regulation, developmental; drosophila melanogaster; cytoskeleton; mesoderm; drosophila proteins; actin related protein 2-3 complex; protein polymerization; cell fusion; myoblast; myoblasts; muscle cell; muscle development; genes, insect; transmission electron microscopy; muscle fibers |
| Journal Title: | BioEssays |
| Volume: | 30 |
| Issue: | 5 |
| ISSN: | 0265-9247 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2008-05-01 |
| Start Page: | 423 |
| End Page: | 431 |
| Language: | English |
| DOI: | 10.1002/bies.20756 |
| PUBMED: | 18404690 |
| PROVIDER: | scopus |
| PMCID: | PMC2664634 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 17 November 2011" - "CODEN: BIOEE" - "Source: Scopus" |
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