Myoblast fusion in fly and vertebrates: New genes, new processes and new perspectives Journal Article

   

Authors:	Richardson, B. E.; Nowak, S. J.; Baylies, M. K.
Article Title:	Myoblast fusion in fly and vertebrates: New genes, new processes and new perspectives
Abstract:	Muscle formation and repair depends critically on the fusion of myoblasts. Despite the importance of this process, little is known about the cellular and molecular mechanisms regulating fusion. Forward genetic screens in Drosophila melanogaster have uncovered genes that, when mutated, prevent myoblast fusion. Analyses of these gene products have indicated that the actin cytoskeleton and its regulation play a central role in the fusion process. In this review, we discuss recent advances in the field, including new imaging approaches to analyze fusion as well as a description of novel genes required for fusion. In particular, we highlight what has been learned about the requirement of a specific actin structure at the site of fusion. We also place these findings from Drosophila within the context of myoblast fusion in vertebrates. © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Ltd.
Keywords:	protein expression; gene mutation; review; nonhuman; genetic analysis; protein domain; protein function; protein analysis; animals; mice; actin; models, biological; protein protein interaction; interleukin 4; vascular cell adhesion molecule 1; cell line; protein binding; gene product; embryo pattern formation; gene function; gene expression regulation; enzyme regulation; transcription regulation; conserved sequence; gene interaction; gene fusion; models, genetic; drosophila melanogaster; protein structure; actins; cell adhesion; cytoskeleton; vertebrate; genetic conservation; actin related protein 2-3 complex; gene location; downstream processing; cell-cell fusion; myoblast fusion; myoblast; enzyme active site; muscle; myoblasts; muscle function; muscle development; genetic regulation; adaptor protein; prostacyclin; wiskott aldrich syndrome protein; regulator gene; rac1 protein; very late activation antigen 4; prostaglandin f2 alpha; blow protein; caveolin 3; cd164 antigen; connectin; dumbfounded protein; elmo protein; hibris protein; irre protein; kette protein; kirre protein; loner protein; mannose receptor; neogenin; rac2 protein; rolling pebbles protein; roughest protein; scar protein; sing protein; sticks and stones protein; fishes
Journal Title:	Traffic
Volume:	9
Issue:	7
ISSN:	1398-9219
Publisher:	Wiley Blackwell
Date Published:	2008-07-01
Start Page:	1050
End Page:	1059
Language:	English
DOI:	10.1111/j.1600-0854.2008.00756.x
PUBMED:	18435820
PROVIDER:	scopus
PMCID:	PMC2677912
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-46349090878&partnerID=40&md5=74c808a54ea793aedf21cf3bc51baa27
Notes:	--- - "Cited By (since 1996): 28" - "Export Date: 17 November 2011" - "CODEN: TRAFF" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/15203