Radiotherapy in the multimodal treatment of extrarenal extracranial malignant rhabdoid tumors Journal Article
| Authors: | Puri, D. R.; Meyers, P. A.; Kraus, D. H.; LaQuaglia, M. P.; Wexler, L. H.; Wolden, S. L. |
| Article Title: | Radiotherapy in the multimodal treatment of extrarenal extracranial malignant rhabdoid tumors |
| Abstract: | Extrarenal extracranial malignant rhabdoid tumors (MRT) are extremely rare and typically lethal. No consensus exists on an optimal treatment approach, and, in particular, the role of radiation therapy (RT) is poorly defined. We report on three children who underwent multimodality treatment including surgery, chemotherapy (CMT), and RT. Two of these patients are alive and without evidence of disease 61/2 and 7 years after diagnosis and one has expired. Our limited experience suggests that RT in the setting of CMT and surgery has the potential to prolong survival with acceptable toxicity, but outcomes are inconsistent and further study is necessary. © 2006 Wiley-Liss, Inc. |
| Keywords: | cancer survival; child; human tissue; preschool child; treatment outcome; treatment response; cancer surgery; disease course; case report; cisplatin; doxorubicin; hepatitis c; skin manifestation; cancer radiotherapy; radiation dose; combined modality therapy; chemotherapy; topotecan; drug megadose; nuclear magnetic resonance imaging; computer assisted tomography; multiple cycle treatment; etoposide; mucosa inflammation; radiotherapy; combination chemotherapy; cyclophosphamide; vincristine; tumor biopsy; cancer therapy; ifosfamide; iodine 125; infant; head and neck neoplasms; brachytherapy; surgery; hypothyroidism; rhabdoid tumor; hoarseness; gamma radiation; malignant rhabdoid tumor; extracranial; extrarenal; diseases in twins |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 50 |
| Issue: | 1 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2008-01-01 |
| Start Page: | 167 |
| End Page: | 169 |
| Language: | English |
| DOI: | 10.1002/pbc.20947 |
| PUBMED: | 16856154 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: PBCEA" - "Source: Scopus" |
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