Chemotherapy only in early-stage Hodgkin lymphoma: More relapses but “same” (or possibly worse) survival – Reconsidering the misguided trend to omit radiotherapy Journal Article
| Author: | Yahalom, J. |
| Article Title: | Chemotherapy only in early-stage Hodgkin lymphoma: More relapses but “same” (or possibly worse) survival – Reconsidering the misguided trend to omit radiotherapy |
| Abstract: | The standard treatment of early-stage Hodgkin lymphoma (ESHL) as recommended by most national guidelines is combined modality treatment (CMT) that includes a short course ABVD followed by a small field of low dose radiotherapy (RT). Recently a trend to treat patients with more chemotherapy alone has been promoted by some claiming that chemotherapy alone is good enough, and the overall survival is similar. These arguments need to be carefully examined, and the risk of more chemotherapy upfront and salvage considered. The suggestion that interim PET will identify patients that can have similar results with chemotherapy alone has recently been questioned by the results of both European and UK studies. It is the subject of this critical review. |
| Keywords: | cancer chemotherapy; cancer survival; treatment failure; overall survival; clinical trial; review; cancer recurrence; doxorubicin; cancer combination chemotherapy; multimodality cancer therapy; cancer radiotherapy; combined modality therapy; cancer staging; positron emission tomography; dacarbazine; quality of life; multiple cycle treatment; radiotherapy; vinblastine; hodgkin disease; bleomycin; hodgkin lymphoma; human; chemotherapy alone; involved-site radiotherapy (isrt) |
| Journal Title: | Current Hematologic Malignancy Reports |
| Volume: | 9 |
| Issue: | 3 |
| ISSN: | 1558-8211 |
| Publisher: | Springer |
| Date Published: | 2014-09-01 |
| Start Page: | 212 |
| End Page: | 216 |
| Language: | English |
| DOI: | 10.1007/s11899-014-0222-5 |
| PROVIDER: | scopus |
| PMCID: | PMC4180027 |
| PUBMED: | 24939521 |
| DOI/URL: | |
| Notes: | Export Date: 1 December 2014 -- Source: Scopus |
