The intestinal flora is required for post-transplant hematopoiesis in recipients of a hematopoietic stem cell transplantation Journal Article


Authors: Staffas, A.; van den Brink, M.
Article Title: The intestinal flora is required for post-transplant hematopoiesis in recipients of a hematopoietic stem cell transplantation
Abstract: Recent studies in both mice and humans have demonstrated that the intestinal microbiota can affect hematopoiesis. Here, we performed experiments in preclinical mouse models for syngeneic and allogeneic HCT. To study the metabolic effects of intestinal flora depletion on post-transplant hematopoiesis in humans, we performed HCT experiments using a metabolic chamber and bomb calorimetry of feces. Taken together, we show that the intestinal microbiota supports post-transplant hematopoietic reconstitution in HCT recipients through its role in dietary energy uptake. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
Keywords: adult; controlled study; review; nonhuman; caloric intake; mouse; animal experiment; animal model; hematopoietic stem cell transplantation; hematopoiesis; intestine flora; feces; recipient; mouse model; calorimetry; preclinical study; male; female
Journal Title: Bone Marrow Transplantation
Volume: 54
Issue: Suppl. 2
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2019-08-01
Start Page: 756
End Page: 758
Language: English
DOI: 10.1038/s41409-019-0612-3
PROVIDER: scopus
PUBMED: 31431719
DOI/URL:
Notes: Review -- Source: Scopus
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