Endogenous small interfering RNAs in animals Journal Article
| Authors: | Okamura, K.; Lai, E. C. |
| Article Title: | Endogenous small interfering RNAs in animals |
| Abstract: | Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice. These findings suggest broad and possibly conserved roles for endogenous RNA interference in regulating host-gene expression and transposable element transcripts. They also raise many questions regarding the biogenesis and function of small regulatory RNAs in animals. © 2008 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | review; nonhuman; animals; mus; gene expression; small interfering rna; rna, small interfering; rna interference; animalia; mammal; drosophila melanogaster; vertebrate; nematoda; transposon; mutant; nematode; pseudogene; eukaryotic initiation factor-2 |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 9 |
| Issue: | 9 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-01-01 |
| Start Page: | 673 |
| End Page: | 678 |
| Language: | English |
| DOI: | 10.1038/nrm2479 |
| PUBMED: | 18719707 |
| PROVIDER: | scopus |
| PMCID: | PMC2729316 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 77" - "Export Date: 17 November 2011" - "CODEN: NRMCB" - "Source: Scopus" |
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