| Abstract: |
A series of 25 cutaneous B‐cell lymphoid proliferations was analyzed for the presence of the (14;18) translocation using the polymerase chain reaction, functional sequences of rearranged chromosomes 14 and 18 were amplified in vitro, and t (14;18) specific sequences were detected in 1 of 14 primary cutaneous B‐cell lymphomas, in 1 of 14 primary nodal B‐cell lymphomas and in none of 3 B‐cell pseudolymphomas. These results indicate that the t (14;18) may occur in a small subset of primary cutaneous lymphoma. However, the difference in incidence of the t (14;18) between primary nodal and primary cutaneous lymphomas suggests that different molecular mechanisms are involved in the pathogenesis of these lymphomas. Copyright © 1992, Wiley Blackwell. All rights reserved |
| Keywords: |
immunohistochemistry; clinical article; human tissue; pathogenesis; polymerase chain reaction; gene amplification; skin neoplasms; b cell lymphoma; lymphoma, b-cell; molecular sequence data; dna, neoplasm; base sequence; skin lymphoma; pseudolymphoma; chromosomes, human, pair 14; chromosomes, human, pair 18; chromosome translocation 14; human; priority journal; article; chromosome translocation 18; translocation (genetics)
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