The importance of brachytherapy technique in the management of primary carcinoma of the vagina Journal Article

Authors: Stock, R. G.; Mychalczak, B.; Armstrong, J. G.; Curtin, J. P.; Harrison, L. B.
Article Title: The importance of brachytherapy technique in the management of primary carcinoma of the vagina
Abstract: This retrospective analysis of 49 cases of primary carcinoma of the vagina treated with radiation therapy alone from 1970-1988 examines the results of treatment with an emphasis on the importance of brachytherapy technique. Thirty-six patients were treated with combined external beam radiation and brachytherapy,11 patients were treated with external beam alone, and two patients were treated with brachytherapy alone. Brachytherapy techniques used included intracavitary implants, temporary Ir-192 interstitial implants, and permanent I-125 interstitial implants. Intracavitary therapy included the use of a fractionated high dose rate intravaginal cylinder, tandem and ovoids, and a low dose rate intravaginal cylinder. The 5-year actuarial survival was 44% for Stage I (six patients), 48% for Stage II (27 patients), 40% for Stage III(10 patients), and 0% for Stage IVa and IVb (six patients). There was a significant increase in the 5-year actuarial survival for those patients who had brachytherapy as part of their treatment compared to those patients treated with external beam alone (50% vs. 9%) (p < .001). For Stages II and III, there was a trend toward improved actuarial and crude disease free survival with the use of a temporary Ir-192 interstitial implant as part of the treatment compared to the use of intracavitary brachytherapy as part of the treatment (80% vs. 45%) (p = 0.25) and (75% vs. 44%) (p = 0.08), respectively. Brachytherapy plays an important role in the management of primary vaginal cancer. A temporary interstitial implant should be used over an intracavitary form of therapy for more invasive disease. © 1992.
Keywords: adult; cancer survival; clinical article; aged; aged, 80 and over; survival analysis; implant; treatment failure; conference paper; radiation dose; cancer staging; lymphatic metastasis; vagina; iodine 125; dosimetry; carcinoma; radiation injuries; brachytherapy; radiation therapy; cancer control; iridium 192; radioisotope therapy; vaginal neoplasms; vagina carcinoma; middle age; prognosis; human; female; priority journal
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Volume: 24
Issue: 4
ISSN: 0360-3016
Publisher: Elsevier Inc.  
Date Published: 1992-01-01
Start Page: 747
End Page: 753
Language: English
DOI: 10.1016/0360-3016(92)90724-v
PUBMED: 1429100
PROVIDER: scopus
Notes: Article -- Source: Scopus
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MSK Authors
  1. John P Curtin
    108 Curtin
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