Brachytherapy for clinically localized prostate cancer: Optimal patient selection Journal Article
| Authors: | Kollmeier, M. A.; Zelefsky, M. J. |
| Article Title: | Brachytherapy for clinically localized prostate cancer: Optimal patient selection |
| Abstract: | The objective of this review is to present an overview of each modality and delineate how to best select patients who are optimal candidates for these treatment approaches. Prostate brachytherapy as a curative modality for clinically localized prostate cancer has become increasingly utilized over the past decade; 25% of all early cancers are now treated this way in the United States (1). The popularity of this treatment strategy lies in the highly conformal nature of radiation dose, low morbidity, patient convenience, and high efficacy rates. Prostate brachytherapy can be delivered by either a permanent interstitial radioactive seed implantation (low dose rate [LDR]) or a temporary interstitial insertion of iridium-192 (Ir192) afterloading catheters. The objective of both of these techniques is to deliver a high dose of radiation to the prostate gland while exposing normal surrounding tissues to minimal radiation dose. Brachytherapy techniques are ideal to achieve this goal given the close proximity of the radiation source to tumor and sharp fall off of the radiation dose cloud proximate to the source. Brachytherapy provides a powerful means of delivering dose escalation above and beyond that achievable with intensity-modulated external beam radiotherapy alone. Careful selection of appropriate patients for these therapies, however, is critical for optimizing both disease-related outcomes and treatment-related toxicity. |
| Keywords: | adult; treatment outcome; aged; disease-free survival; middle aged; androgen; review; multimodality cancer therapy; patient selection; clinical trials as topic; disease free survival; radiation dose; combined modality therapy; follow up; methodology; follow-up studies; neoplasm; adenocarcinoma; statistics; radiotherapy dosage; age factors; pathology; radiation injury; age; prostate cancer; cancer invasion; prostatic neoplasms; instrumentation; prostate tumor; radiation injuries; brachytherapy; radiation therapy; neoplasm invasiveness; antineoplastic agents, hormonal; antineoplastic hormone agonists and antagonists; androgens; neoplasms, hormone-dependent; clinical trial (topic); micturition disorder; organs at risk; urination disorders |
| Journal Title: | Archivos Españoles de Urología |
| Volume: | 64 |
| Issue: | 8 |
| ISSN: | 0004-0614 |
| Publisher: | Iniestares, S.A. |
| Date Published: | 2011-10-01 |
| Start Page: | 847 |
| End Page: | 856 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 22052766 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: AEURA" - "Source: Scopus" |
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